Summary
This is the summary of UniProt entry ROCK1_HUMAN (Q13464).
| Description: | Rho-associated protein kinase 1 EC=2.7.11.1 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 1354 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam A | Pkinase | 76 | 338 |
| Pfam A | Pkinase_C | 358 | 402 |
| disorder | n/a | 366 | 375 |
| disorder | n/a | 379 | 380 |
| disorder | n/a | 408 | 427 |
| coiled_coil | n/a | 432 | 560 |
| disorder | n/a | 439 | 441 |
| disorder | n/a | 443 | 452 |
| disorder | n/a | 457 | 483 |
| Pfam A | HR1 | 458 | 537 |
| disorder | n/a | 485 | 486 |
| disorder | n/a | 488 | 490 |
| disorder | n/a | 492 | 543 |
| low_complexity | n/a | 503 | 516 |
| disorder | n/a | 546 | 552 |
| disorder | n/a | 554 | 580 |
| coiled_coil | n/a | 568 | 602 |
| disorder | n/a | 583 | 598 |
| disorder | n/a | 602 | 612 |
| disorder | n/a | 614 | 629 |
| coiled_coil | n/a | 624 | 672 |
| disorder | n/a | 632 | 633 |
| disorder | n/a | 635 | 636 |
| disorder | n/a | 638 | 668 |
| disorder | n/a | 670 | 672 |
| coiled_coil | n/a | 677 | 701 |
| disorder | n/a | 688 | 702 |
| disorder | n/a | 704 | 729 |
| coiled_coil | n/a | 713 | 789 |
| low_complexity | n/a | 715 | 731 |
| disorder | n/a | 731 | 732 |
| disorder | n/a | 752 | 764 |
| disorder | n/a | 766 | 773 |
| disorder | n/a | 797 | 799 |
| coiled_coil | n/a | 797 | 845 |
| disorder | n/a | 801 | 802 |
| disorder | n/a | 836 | 840 |
| disorder | n/a | 843 | 844 |
| coiled_coil | n/a | 853 | 898 |
| low_complexity | n/a | 861 | 878 |
| disorder | n/a | 868 | 869 |
| disorder | n/a | 871 | 882 |
| disorder | n/a | 886 | 896 |
| disorder | n/a | 900 | 901 |
| disorder | n/a | 919 | 943 |
| coiled_coil | n/a | 938 | 987 |
| Pfam A | Rho_Binding | 948 | 1014 |
| disorder | n/a | 949 | 950 |
| disorder | n/a | 952 | 957 |
| disorder | n/a | 959 | 963 |
| low_complexity | n/a | 964 | 980 |
| disorder | n/a | 965 | 976 |
| disorder | n/a | 984 | 990 |
| disorder | n/a | 999 | 1003 |
| disorder | n/a | 1014 | 1015 |
| disorder | n/a | 1017 | 1036 |
| coiled_coil | n/a | 1020 | 1065 |
| disorder | n/a | 1038 | 1041 |
| disorder | n/a | 1050 | 1055 |
| disorder | n/a | 1063 | 1068 |
| coiled_coil | n/a | 1073 | 1100 |
| disorder | n/a | 1081 | 1082 |
| disorder | n/a | 1106 | 1112 |
| disorder | n/a | 1117 | 1121 |
| Pfam A | PH | 1119 | 1317 |
| disorder | n/a | 1217 | 1219 |
| disorder | n/a | 1311 | 1312 |
| disorder | n/a | 1323 | 1330 |
| disorder | n/a | 1336 | 1351 |
| disorder | n/a | 1353 | 1354 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q13464. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MSTGDSFETR FEKMDNLLRD PKSEVNSDCL LDGLDALVYD LDFPALRKNK
50 51
NIDNFLSRYK DTINKIRDLR MKAEDYEVVK VIGRGAFGEV QLVRHKSTRK
100 101
VYAMKLLSKF EMIKRSDSAF FWEERDIMAF ANSPWVVQLF YAFQDDRYLY
150 151
MVMEYMPGGD LVNLMSNYDV PEKWARFYTA EVVLALDAIH SMGFIHRDVK
200 201
PDNMLLDKSG HLKLADFGTC MKMNKEGMVR CDTAVGTPDY ISPEVLKSQG
250 251
GDGYYGRECD WWSVGVFLYE MLVGDTPFYA DSLVGTYSKI MNHKNSLTFP
300 301
DDNDISKEAK NLICAFLTDR EVRLGRNGVE EIKRHLFFKN DQWAWETLRD
350 351
TVAPVVPDLS SDIDTSNFDD LEEDKGEEET FPIPKAFVGN QLPFVGFTYY
400 401
SNRRYLSSAN PNDNRTSSNA DKSLQESLQK TIYKLEEQLH NEMQLKDEME
450 451
QKCRTSNIKL DKIMKELDEE GNQRRNLEST VSQIEKEKML LQHRINEYQR
500 501
KAEQENEKRR NVENEVSTLK DQLEDLKKVS QNSQLANEKL SQLQKQLEEA
550 551
NDLLRTESDT AVRLRKSHTE MSKSISQLES LNRELQERNR ILENSKSQTD
600 601
KDYYQLQAIL EAERRDRGHD SEMIGDLQAR ITSLQEEVKH LKHNLEKVEG
650 651
ERKEAQDMLN HSEKEKNNLE IDLNYKLKSL QQRLEQEVNE HKVTKARLTD
700 701
KHQSIEEAKS VAMCEMEKKL KEEREAREKA ENRVVQIEKQ CSMLDVDLKQ
750 751
SQQKLEHLTG NKERMEDEVK NLTLQLEQES NKRLLLQNEL KTQAFEADNL
800 801
KGLEKQMKQE INTLLEAKRL LEFELAQLTK QYRGNEGQMR ELQDQLEAEQ
850 851
YFSTLYKTQV KELKEEIEEK NRENLKKIQE LQNEKETLAT QLDLAETKAE
900 901
SEQLARGLLE EQYFELTQES KKAASRNRQE ITDKDHTVSR LEEANSMLTK
950 951
DIEILRRENE ELTEKMKKAE EEYKLEKEEE ISNLKAAFEK NINTERTLKT
1000 1001
QAVNKLAEIM NRKDFKIDRK KANTQDLRKK EKENRKLQLE LNQEREKFNQ
1050 1051
MVVKHQKELN DMQAQLVEEC AHRNELQMQL ASKESDIEQL RAKLLDLSDS
1100 1101
TSVASFPSAD ETDGNLPESR IEGWLSVPNR GNIKRYGWKK QYVVVSSKKI
1150 1151
LFYNDEQDKE QSNPSMVLDI DKLFHVRPVT QGDVYRAETE EIPKIFQILY
1200 1201
ANEGECRKDV EMEPVQQAEK TNFQNHKGHE FIPTLYHFPA NCDACAKPLW
1250 1251
HVFKPPPALE CRRCHVKCHR DHLDKKEDLI CPCKVSYDVT SARDMLLLAC
1300 1301
SQDEQKKWVT HLVKKIPKNP PSGFVRASPR TLSTRSTANQ SFRKVVKNTS
1350 1351
GKTS
1354
Show the unformatted sequence. |
| Checksums: |
CRC64:93078CBB009A6F27
MD5:092461d2e13ad54ee72be3459cc73d02
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.