Summary
This is the summary of UniProt entry FKBP8_HUMAN (Q14318).
| Description: | Peptidyl-prolyl cis-trans isomerase FKBP8 EC=5.2.1.8 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 412 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam B | Pfam-B_32202 | 1 | 79 |
| disorder | n/a | 1 | 96 |
| low_complexity | n/a | 2 | 16 |
| low_complexity | n/a | 25 | 57 |
| coiled_coil | n/a | 27 | 47 |
| low_complexity | n/a | 78 | 92 |
| disorder | n/a | 104 | 140 |
| Pfam A | FKBP_C | 113 | 201 |
| Pfam A | TPR_1 | 272 | 305 |
| Pfam A | TPR_1 | 306 | 339 |
| transmembrane | n/a | 388 | 410 |
| low_complexity | n/a | 391 | 410 |
Show or hide domain scores.
Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
Note: it can take a few seconds for this image to be generated and loaded.
Show sources update panel.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q14318. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MASCAEPSEP SAPLPAGVPP LEDFEVLDGV EDAEGEEEEE EEEEEEDDLS
50 51
ELPPLEDMGQ PPAEEAEQPG ALAREFLAAM EPEPAPAPAP EEWLDILGNG
100 101
LLRKKTLVPG PPGSSRPVKG QVVTVHLQTS LENGTRVQEE PELVFTLGDC
150 151
DVIQALDLSV PLMDVGETAM VTADSKYCYG PQGRSPYIPP HAALCLEVTL
200 201
KTAVDGPDLE MLTGQERVAL ANRKRECGNA HYQRADFVLA ANSYDLAIKA
250 251
ITSSAKVDMT FEEEAQLLQL KVKCLNNLAA SQLKLDHYRA ALRSCSLVLE
300 301
HQPDNIKALF RKGKVLAQQG EYSEAIPILR AALKLEPSNK TIHAELSKLV
350 351
KKHAAQRSTE TALYRKMLGN PSRLPAKCPG KGAWSIPWKW LFGATAVALG
400 401
GVALSVVIAA RN
412
Show the unformatted sequence. |
| Checksums: |
CRC64:887C25ADE71EBA8D
MD5:98aed2aada093d893e5f656d2f9f6be3
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| FKBP_C | 113 - 201 | 2AWG | A | 113 - 201 | Jmol AstexViewer SPICE |
| 2D9F | A | 30 - 119 | Jmol AstexViewer SPICE | ||
| 2F2D | A | 56 - 144 | Jmol AstexViewer SPICE | ||
| 2JWX | A | 56 - 145 | Jmol AstexViewer SPICE | ||
| 3EY6 | A | 56 - 144 | Jmol AstexViewer SPICE |