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169  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MK14_HUMAN (Q16539)

Summary

This is the summary of UniProt entry MK14_HUMAN (Q16539).

Description: Mitogen-activated protein kinase 14 EC=2.7.11.24
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 360 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A Pkinase 24 308
low_complexity n/a 299 312
disorder n/a 319 322
disorder n/a 353 354
disorder n/a 356 360

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q16539. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV
50
51
AVKKLSRPFQ SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN
100
101
DVYLVTHLMG ADLNNIVKCQ KLTDDHVQFL IYQILRGLKY IHSADIIHRD
150
151
LKPSNLAVNE DCELKILDFG LARHTDDEMT GYVATRWYRA PEIMLNWMHY
200
201
NQTVDIWSVG CIMAELLTGR TLFPGTDHID QLKLILRLVG TPGAELLKKI
250
251
SSESARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA
300
301
QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP
350
351
PPLDQEEMES                                            
360
 

Show the unformatted sequence.

Checksums:
CRC64:286C81D0487618B3
MD5:4f35ee5c7e10d2f8f66e8580cd2f9708

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 24 - 308 1A9U A 24 - 308 Jmol AstexViewer SPICE
1BL6 A 24 - 308 Jmol AstexViewer SPICE
1BL7 A 24 - 308 Jmol AstexViewer SPICE
1BMK A 24 - 308 Jmol AstexViewer SPICE
1DI9 A 24 - 308 Jmol AstexViewer SPICE
1KV1 A 24 - 308 Jmol AstexViewer SPICE
1KV2 A 24 - 308 Jmol AstexViewer SPICE
1M7Q A 24 - 308 Jmol AstexViewer SPICE
1OUK A 24 - 308 Jmol AstexViewer SPICE
1OUY A 24 - 308 Jmol AstexViewer SPICE
1OVE A 24 - 308 Jmol AstexViewer SPICE
1OZ1 A 24 - 308 Jmol AstexViewer SPICE
1R39 A 24 - 308 Jmol AstexViewer SPICE
1R3C A 24 - 308 Jmol AstexViewer SPICE
1W7H A 24 - 308 Jmol AstexViewer SPICE
1W82 A 24 - 308 Jmol AstexViewer SPICE
1W83 A 24 - 308 Jmol AstexViewer SPICE
1W84 A 24 - 308 Jmol AstexViewer SPICE
1WBN A 24 - 308 Jmol AstexViewer SPICE
1WBO A 24 - 308 Jmol AstexViewer SPICE
1WBS A 24 - 308 Jmol AstexViewer SPICE
1WBT A 24 - 308 Jmol AstexViewer SPICE
1WBV A 24 - 308 Jmol AstexViewer SPICE
1WBW A 24 - 308 Jmol AstexViewer SPICE
1WFC A 24 - 308 Jmol AstexViewer SPICE
1YQJ A 24 - 308 Jmol AstexViewer SPICE
1ZYJ A 24 - 308 Jmol AstexViewer SPICE
1ZZ2 A 24 - 308 Jmol AstexViewer SPICE
1ZZL A 24 - 308 Jmol AstexViewer SPICE
2BAJ A 24 - 308 Jmol AstexViewer SPICE
2BAK A 24 - 308 Jmol AstexViewer SPICE
2BAL A 24 - 308 Jmol AstexViewer SPICE
2BAQ A 24 - 308 Jmol AstexViewer SPICE
2FSL X 24 - 308 Jmol AstexViewer SPICE
2FSM X 24 - 308 Jmol AstexViewer SPICE
2FSO X 24 - 308 Jmol AstexViewer SPICE
2FST X 24 - 308 Jmol AstexViewer SPICE
2GFS A 24 - 308 Jmol AstexViewer SPICE
2I0H A 24 - 308 Jmol AstexViewer SPICE
2NPQ A 24 - 308 Jmol AstexViewer SPICE
2OKR A 24 - 308 Jmol AstexViewer SPICE
D 24 - 308 Jmol AstexViewer SPICE
2ONL A 24 - 308 Jmol AstexViewer SPICE
B 24 - 308 Jmol AstexViewer SPICE
2QD9 A 24 - 308 Jmol AstexViewer SPICE
2RG5 A 24 - 308 Jmol AstexViewer SPICE
2RG6 A 24 - 308 Jmol AstexViewer SPICE
2Y8O A 24 - 308 Jmol AstexViewer SPICE
2YIS A 24 - 308 Jmol AstexViewer SPICE
2YIW A 24 - 308 Jmol AstexViewer SPICE
2YIX A 24 - 308 Jmol AstexViewer SPICE
2ZAZ A 24 - 308 Jmol AstexViewer SPICE
2ZB0 A 24 - 308 Jmol AstexViewer SPICE
2ZB1 A 24 - 308 Jmol AstexViewer SPICE
3BV2 A 24 - 308 Jmol AstexViewer SPICE
3BV3 A 24 - 308 Jmol AstexViewer SPICE
3BX5 A 24 - 308 Jmol AstexViewer SPICE
3C5U A 24 - 308 Jmol AstexViewer SPICE
3CTQ A 24 - 308 Jmol AstexViewer SPICE
3D7Z A 24 - 308 Jmol AstexViewer SPICE
3D83 A 24 - 308 Jmol AstexViewer SPICE
3DS6 A 24 - 308 Jmol AstexViewer SPICE
B 24 - 308 Jmol AstexViewer SPICE
C 24 - 308 Jmol AstexViewer SPICE
D 24 - 308 Jmol AstexViewer SPICE
3DT1 A 24 - 308 Jmol AstexViewer SPICE
3E92 A 24 - 308 Jmol AstexViewer SPICE
3E93 A 24 - 308 Jmol AstexViewer SPICE
3FC1 X 24 - 308 Jmol AstexViewer SPICE
3FI4 A 24 - 308 Jmol AstexViewer SPICE
3FKL A 24 - 308 Jmol AstexViewer SPICE
3FKN A 24 - 308 Jmol AstexViewer SPICE
3FKO A 24 - 308 Jmol AstexViewer SPICE
3FL4 A 24 - 308 Jmol AstexViewer SPICE
3FLN C 24 - 308 Jmol AstexViewer SPICE
3FLQ A 24 - 308 Jmol AstexViewer SPICE
3FLS A 24 - 308 Jmol AstexViewer SPICE
3FLW A 24 - 308 Jmol AstexViewer SPICE
3FLY A 24 - 308 Jmol AstexViewer SPICE
3FLZ A 24 - 308 Jmol AstexViewer SPICE
3FMH A 24 - 308 Jmol AstexViewer SPICE
3FMJ A 24 - 308 Jmol AstexViewer SPICE
3FMK A 24 - 308 Jmol AstexViewer SPICE
3FML A 24 - 308 Jmol AstexViewer SPICE
3FMM A 24 - 308 Jmol AstexViewer SPICE
3FMN A 24 - 308 Jmol AstexViewer SPICE
3FSF A 24 - 308 Jmol AstexViewer SPICE
3FSK A 24 - 308 Jmol AstexViewer SPICE
3GC7 A 24 - 308 Jmol AstexViewer SPICE
3GCP A 24 - 308 Jmol AstexViewer SPICE
3GCQ A 24 - 308 Jmol AstexViewer SPICE
3GCS A 24 - 308 Jmol AstexViewer SPICE
3GCU A 24 - 308 Jmol AstexViewer SPICE
B 24 - 308 Jmol AstexViewer SPICE
3GCV A 24 - 308 Jmol AstexViewer SPICE
3GFE A 24 - 308 Jmol AstexViewer SPICE
3GI3 A 24 - 308 Jmol AstexViewer SPICE
3HA8 A 24 - 308 Jmol AstexViewer SPICE
3HEC A 24 - 308 Jmol AstexViewer SPICE
3HEG A 24 - 308 Jmol AstexViewer SPICE
3HL7 A 23 - 307 Jmol AstexViewer SPICE
3HLL A 24 - 308 Jmol AstexViewer SPICE
3HP2 A 24 - 308 Jmol AstexViewer SPICE
3HP5 A 24 - 308 Jmol AstexViewer SPICE
3HRB A 24 - 308 Jmol AstexViewer SPICE
3HUB A 24 - 308 Jmol AstexViewer SPICE
3HUC A 24 - 308 Jmol AstexViewer SPICE
3HV3 A 24 - 308 Jmol AstexViewer SPICE
3HV4 A 24 - 308 Jmol AstexViewer SPICE
B 24 - 308 Jmol AstexViewer SPICE
3HV5 A 24 - 308 Jmol AstexViewer SPICE
B 24 - 308 Jmol AstexViewer SPICE
3HV6 A 24 - 308 Jmol AstexViewer SPICE
3HV7 A 24 - 308 Jmol AstexViewer SPICE
3HVC A 24 - 308 Jmol AstexViewer SPICE
3IPH A 24 - 308 Jmol AstexViewer SPICE
3ITZ A 24 - 308 Jmol AstexViewer SPICE
3IW5 A 24 - 308 Jmol AstexViewer SPICE
3IW6 A 24 - 308 Jmol AstexViewer SPICE
3IW7 A 24 - 308 Jmol AstexViewer SPICE
3IW8 A 24 - 308 Jmol AstexViewer SPICE
3K3I A 24 - 308 Jmol AstexViewer SPICE
3K3J A 24 - 308 Jmol AstexViewer SPICE
3KF7 A 24 - 308 Jmol AstexViewer SPICE
3KQ7 A 24 - 308 Jmol AstexViewer SPICE
3L8S A 24 - 308 Jmol AstexViewer SPICE
3L8X A 24 - 308 Jmol AstexViewer SPICE
3LFA A 24 - 308 Jmol AstexViewer SPICE
3LFB A 24 - 308 Jmol AstexViewer SPICE
3LFC A 24 - 308 Jmol AstexViewer SPICE
3LFD A 24 - 308 Jmol AstexViewer SPICE
3LFE A 24 - 308 Jmol AstexViewer SPICE
3LFF A 24 - 308 Jmol AstexViewer SPICE
3LHJ A 24 - 308 Jmol AstexViewer SPICE
3MGY A 24 - 308 Jmol AstexViewer SPICE
3MH0 A 24 - 308 Jmol AstexViewer SPICE
3MH1 A 24 - 308 Jmol AstexViewer SPICE
3MH2 A 24 - 308 Jmol AstexViewer SPICE
3MH3 A 24 - 308 Jmol AstexViewer SPICE
3MPA A 24 - 308 Jmol AstexViewer SPICE
3MPT A 24 - 308 Jmol AstexViewer SPICE
3MVL A 24 - 308 Jmol AstexViewer SPICE
B 24 - 308 Jmol AstexViewer SPICE
3MVM A 24 - 308 Jmol AstexViewer SPICE
B 24 - 308 Jmol AstexViewer SPICE
3MW1 A 24 - 308 Jmol AstexViewer SPICE
3NEW A 24 - 308 Jmol AstexViewer SPICE
3NNU A 24 - 308 Jmol AstexViewer SPICE
3NNV A 24 - 308 Jmol AstexViewer SPICE
3NNW A 24 - 308 Jmol AstexViewer SPICE
3NNX A 24 - 308 Jmol AstexViewer SPICE
3NWW A 24 - 308 Jmol AstexViewer SPICE
3O8P A 24 - 308 Jmol AstexViewer SPICE
3O8T A 24 - 308 Jmol AstexViewer SPICE
3O8U A 24 - 308 Jmol AstexViewer SPICE
3OBG A 24 - 308 Jmol AstexViewer SPICE
3OBJ A 24 - 308 Jmol AstexViewer SPICE
3OC1 A 24 - 308 Jmol AstexViewer SPICE
3OCG A 24 - 308 Jmol AstexViewer SPICE
3OD6 X 24 - 308 Jmol AstexViewer SPICE
3ODY X 24 - 308 Jmol AstexViewer SPICE
3ODZ X 24 - 308 Jmol AstexViewer SPICE
3OEF X 24 - 308 Jmol AstexViewer SPICE
3PG3 A 24 - 308 Jmol AstexViewer SPICE
3QUD A 24 - 308 Jmol AstexViewer SPICE
3QUE A 24 - 308 Jmol AstexViewer SPICE
3RIN A 24 - 308 Jmol AstexViewer SPICE
3ROC A 24 - 308 Jmol AstexViewer SPICE
3S3I A 24 - 308 Jmol AstexViewer SPICE
3S4Q A 24 - 308 Jmol AstexViewer SPICE
3ZSG A 24 - 308 Jmol AstexViewer SPICE
3ZSH A 24 - 308 Jmol AstexViewer SPICE
3ZSI A 24 - 308 Jmol AstexViewer SPICE
3ZYA A 24 - 308 Jmol AstexViewer SPICE
4A9Y A 24 - 308 Jmol AstexViewer SPICE
4AA0 A 24 - 308 Jmol AstexViewer SPICE
4AA4 A 24 - 308 Jmol AstexViewer SPICE
4AA5 A 24 - 308 Jmol AstexViewer SPICE
4AAC A 24 - 308 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.