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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: NFE2_HUMAN (Q16621)

Summary

This is the summary of UniProt entry NFE2_HUMAN (Q16621).

Description: Transcription factor NF-E2 45 kDa subunit
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 373 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 1 20
disorder n/a 27 28
disorder n/a 32 64
low_complexity n/a 50 68
disorder n/a 67 73
disorder n/a 76 92
low_complexity n/a 77 86
disorder n/a 94 100
low_complexity n/a 105 120
disorder n/a 111 112
disorder n/a 123 171
low_complexity n/a 171 182
disorder n/a 195 231
Pfam A bZIP_Maf 237 330
disorder n/a 278 279
coiled_coil n/a 284 318
low_complexity n/a 294 317
disorder n/a 305 307
disorder n/a 312 314
disorder n/a 345 349
disorder n/a 372 373

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q16621. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSPCPPQQSR NRVIQLSTSE LGEMELTWQE IMSITELQGL NAPSEPSFEP
50
51
QAPAPYLGPP PPTTYCPCSI HPDSGFPLPP PPYELPASTS HVPDPPYSYG
100
101
NMAIPVSKPL SLSGLLSEPL QDPLALLDIG LPAGPPKPQE DPESDSGLSL
150
151
NYSDAESLEL EGTEAGRRRS EYVEMYPVEY PYSLMPNSLA HSNYTLPAAE
200
201
TPLALEPSSG PVRAKPTARG EAGSRDERRA LAMKIPFPTD KIVNLPVDDF
250
251
NELLARYPLT ESQLALVRDI RRRGKNKVAA QNCRKRKLET IVQLERELER
300
301
LTNERERLLR ARGEADRTLE VMRQQLTELY RDIFQHLRDE SGNSYSPEEY
350
351
ALQQAADGTI FLVPRGTKME ATD                             
373
 

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Checksums:
CRC64:A9821170FB2ED67C
MD5:9bbb29a38125abbd42ff887beb498d17

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
bZIP_Maf 237 - 293 2KZ5 A 35 - 91 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.