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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: SSH2_HUMAN (Q76I76)

Summary

This is the summary of UniProt entry SSH2_HUMAN (Q76I76).

Description: Protein phosphatase Slingshot homolog 2 EC=3.1.3.16 EC=3.1.3.48
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1423 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 1 37
low_complexity n/a 9 18
disorder n/a 55 70
disorder n/a 107 111
disorder n/a 121 124
disorder n/a 223 227
disorder n/a 235 242
Pfam A DEK_C 250 303
Pfam A DSPc 315 445
disorder n/a 458 461
low_complexity n/a 459 469
disorder n/a 488 496
disorder n/a 498 499
disorder n/a 502 510
disorder n/a 581 582
disorder n/a 584 585
disorder n/a 587 596
Pfam B Pfam-B_4003 589 694
disorder n/a 603 606
disorder n/a 608 609
disorder n/a 612 641
low_complexity n/a 623 637
disorder n/a 666 680
disorder n/a 682 687
disorder n/a 690 735
disorder n/a 749 754
disorder n/a 760 761
disorder n/a 763 765
disorder n/a 767 1006
low_complexity n/a 838 852
Pfam B Pfam-B_12612 856 918
low_complexity n/a 871 884
disorder n/a 1011 1044
disorder n/a 1046 1048
disorder n/a 1055 1059
disorder n/a 1061 1115
disorder n/a 1128 1131
disorder n/a 1136 1177
disorder n/a 1187 1215
disorder n/a 1217 1232
disorder n/a 1235 1236
disorder n/a 1242 1249
disorder n/a 1284 1287
disorder n/a 1292 1327
Pfam B Pfam-B_6451 1323 1351
disorder n/a 1344 1345
Pfam B Pfam-B_15529 1353 1421
disorder n/a 1361 1363
disorder n/a 1367 1370
disorder n/a 1376 1377
disorder n/a 1385 1423

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q76I76. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MALVTVQRSP TPSTTSSPCA SEADSGEEEC RSQPRSISES FLTVKGAALF
50
51
LPRGNGSSTP RISHRRNKHA GDLQQHLQAM FILLRPEDNI RLAVRLESTY
100
101
QNRTRYMVVV STNGRQDTEE SIVLGMDFSS NDSSTCTMGL VLPLWSDTLI
150
151
HLDGDGGFSV STDNRVHIFK PVSVQAMWSA LQSLHKACEV ARAHNYYPGS
200
201
LFLTWVSYYE SHINSDQSSV NEWNAMQDVQ SHRPDSPALF TDIPTERERT
250
251
ERLIKTKLRE IMMQKDLENI TSKEIRTELE MQMVCNLREF KEFIDNEMIV
300
301
ILGQMDSPTQ IFEHVFLGSE WNASNLEDLQ NRGVRYILNV TREIDNFFPG
350
351
VFEYHNIRVY DEEATDLLAY WNDTYKFISK AKKHGSKCLV HCKMGVSRSA
400
401
STVIAYAMKE YGWNLDRAYD YVKERRTVTK PNPSFMRQLE EYQGILLASK
450
451
QRHNKLWRSH SDSDLSDHHE PICKPGLELN KKDITTSADQ IAEVKTMESH
500
501
PPIPPVFVEH MVPQDANQKG LCTKERMICL EFTSREFHAG QIEDELNLND
550
551
INGCSSGCCL NESKFPLDNC HASKALIQPG HVPEMANKFP DLTVEDLETD
600
601
ALKADMNVHL LPMEELTSPL KDPPMSPDPE SPSPQPSCQT EISDFSTDRI
650
651
DFFSALEKFV ELSQETRSRS FSHSRMEELG GGRNESCRLS VVEVAPSKVT
700
701
ADDQRSSSLS NTPHASEESS MDEEQSKAIS ELVSPDIFMQ SHSENAISVK
750
751
EIVTEIESIS QGVGQIQLKG DILPNPCHTP KKNSIHELLL ERAQTPENKP
800
801
GHMEQDEDSC TAQPELAKDS GMCNPEGCLT THSSIADLEE GEPAEGEQEL
850
851
QGSGMHPGAK WYPGSVRRAT LEFEERLRQE QEHHGAAPTC TSLSTRKNSK
900
901
NDSSVADLAP KGKSDEAPPE HSFVLKEPEM SKGKGKYSGS EAGSLSHSEQ
950
951
NATVPAPRVL EFDHLPDPQE GPGSDTGTQQ EGVLKDLRTV IPYQESETQA
1000
1001
VPLPLPKRVE IIEYTHIVTS PNHTGPGSEI ATSEKSGEQG LRKVNMEKSV
1050
1051
TVLCTLDENL NRTLDPNQVS LHPQVLPLPH SSSPEHNRPT DHPTSILSSP
1100
1101
EDRGSSLSTA LETAAPFVSH TTHLLSASLD YLHPQTMVHL EGFTEQSSTT
1150
1151
DEPSAEQVSW EESQESPLSS GSEVPYKDSQ LSSADLSLIS KLGDNTGELQ
1200
1201
EKMDPLPVAC RLPHSSSSEN IKSLSHSPGV VKERAKEIES RVVFQAGLTK
1250
1251
PSQMRRSASL AKLGYLDLCK DCLPEREPAS CESPHLKLLQ PFLRTDSGMH
1300
1301
AMEDQESLEN PGAPHNPEPT KSFVEQLTTT ECIVQSKPVE RPLVQYAKEF
1350
1351
GSSQQYLLPR AGLELTSSEG GLPVLQTQGL QCACPAPGLA VAPRQQHGRT
1400
1401
HPLRRLKKAN DKKRTTNPFY NTM                             
1423
 

Show the unformatted sequence.

Checksums:
CRC64:23D0B59C97D6BE38
MD5:c399c4e9f2ecd18a932b67f6df4586c8

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DSPc 315 - 445 2NT2 A 315 - 445 Jmol AstexViewer SPICE
B 315 - 445 Jmol AstexViewer SPICE
C 315 - 445 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.