Summary

This is the summary of UniProt entry UBE3B_HUMAN (Q7Z3V4).

Description:

Ubiquitin-protein ligase E3B EC=6.3.2.-

Source organism:

Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.

Length:

1068 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source	Domain	Start	End	Gathering threshold (bits)		Score (bits)		E-value
Source	Domain	Start	End	Sequence	Domain	Sequence	Domain	Sequence	Domain
Pfam A	IQ	30	50	20.30	11.10	21.40	21.40	0.18	0.18
Pfam B	Pfam-B_18279	211	279	n/a	n/a	n/a	n/a	n/a	n/a
low_complexity	n/a	468	486	n/a	n/a	n/a	n/a	n/a	n/a
Pfam A	HECT	736	1068	20.40	20.40	306.60	305.90	2.7e-88	4.6e-88

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

We generate the topmost image from data in the Pfam database, but subsequent images are constructed on-the-fly using data retrieved from other sources using the Distributed Annotation System (DAS). DAS is a system for sharing sequence annotations in a standard format and we use it to find features and sequence information from a wide variety of other sources, from UniProt to InterPro to Superfamily.

Each DAS source is represented in a new track, although some sources may generate more than one track, if they have features which overlap. Each feature that we find is shown as a simple box, positioned according to its residue position on the sequence.

Moving your mouse over a feature in the display will highlight the feature and show a tooltip giving details of the feature. If the DAS source supplied a URL, you can also click on the feature to visit that URL. In some browsers you will also see a thin, vertical cursor, which follows the mouse and shows the residue position within the sequence.

You can turn DAS sources on and off using the control panel under the sequence images. Check the boxes for the DAS sources that you want to see; uncheck those that you are not interested in. Press Update to query the new set of DAS sources and re-generate the image. Note that if you have lots of sources turned on, the time taken to generate the images will increase. You can see the homepage for each of the DAS sources by clicking on its name in the update panel. The "source" link next to each source points directly at the DAS source. Depending on how the source is configured, that link may return some usage information or simply an XML fragment with the response to the empty query that you just made.

Please note: this is an experimental feature and there are several known bugs and limitations. Please be patient as we improve the tool.

Note: it can take a few seconds for this image to be generated and loaded.

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q7Z3V4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:

MFTLSQTSRA WFIDRARQAR EERLVQKERE RAAVVIQAHV RSFLCRSRLQ

RDIRREIDDF FKADDPESTK RSALCIFKIA RKLLFLFRIK EDNERFEKLC

100

101

RSILSSMDAE NEPKVWYVSL ACSKDLTLLW IQQIKNILWY CCDFLKQLKP

150

151

EILQDSRLIT LYLTMLVTFT DTSTWKILRG KGESLRPAMN HICANIMGHL

200

201

NQHGFYSVLQ ILLTRGLARP RPCLSKGTLT AAFSLALRPV IAAQFSDNLI

250

251

RPFLIHIMSV PALVTHLSTV TPERLTVLES HDMLRKFIIF LRDQDRCRDV

300

301

CESLEGCHTL CLMGNLLHLG SLSPRVLEEE TDGFVSLLTQ TLCYCRKYVS

350

351

QKKSNLTHWH PVLGWFSQSV DYGLNESMHL ITKQLQFLWG VPLIRIFFCD

400

401

ILSKKLLESQ EPAHAQPASP QNVLPVKSLL KRAFQKSASV RNILRPVGGK

450

451

RVDSAEVQKV CNICVLYQTS LTTLTQIRLQ ILTGLTYLDD LLPKLWAFIC

500

501

ELGPHGGLKL FLECLNNDTE ESKQLLAMLM LFCDCSRHLI TILDDIEVYE

550

551

EQISFKLEEL VTISSFLNSF VFKMIWDGIV ENAKGETLEL FQSVHGWLMV

600

601

LYERDCRRRF TPEDHWLRKD LKPSVLFQEL DRDRKRAQLI LQYIPHVIPH

650

651

KNRVLLFRTM VTKEKEKLGL VETSSASPHV THITIRRSRM LEDGYEQLRQ

700

701

LSQHAMKGVI RVKFVNDLGV DEAGIDQDGV FKEFLEEIIK RVFDPALNLF

750

751

KTTSGDERLY PSPTSYIHEN YLQLFEFVGK MLGKAVYEGI VVDVPFASFF

800

801

LSQLLGHHHS VFYSSVDELP SLDSEFYKNL TSIKRYDGDI TDLGLTLSYD

850

851

EDVMGQLVCH ELIPGGKTIP VTNENKISYI HLMAHFRMHT QIKNQTAALI

900

901

SGFRSIIKPE WIRMFSTPEL QRLISGDNAE IDLEDLKKHT VYYGGFHGSH

950

951

RVIIWLWDIL ASDFTPDERA MFLKFVTSCS RPPLLGFAYL KPPFSIRCVE

1000

1001

VSDDQDTGDT LGSVLRGFFT IRKREPGGRL PTSSTCFNLL KLPNYSKKSV

1050

1051

LREKLRYAIS MNTGFELS

1068

Show the unformatted sequence.

Checksums:

CRC64:A1740A3DDC5E1A4D

MD5:a7afc1a0640561f0dab0179981cab9fe

Protein: UBE3B_HUMAN (Q7Z3V4)

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Summary

Pfam domains

Sequence annotations

Sequence information