Summary
This is the summary of UniProt entry TBCD1_HUMAN (Q86TI0).
| Description: | TBC1 domain family member 1 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 1168 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam B | Pfam-B_3043 | 1 | 159 |
| disorder | n/a | 145 | 147 |
| Pfam B | Pfam-B_9914 | 169 | 202 |
| disorder | n/a | 203 | 234 |
| low_complexity | n/a | 257 | 267 |
| Pfam A | PID | 277 | 381 |
| low_complexity | n/a | 368 | 385 |
| disorder | n/a | 413 | 416 |
| disorder | n/a | 430 | 436 |
| Pfam B | Pfam-B_8829 | 457 | 562 |
| disorder | n/a | 465 | 484 |
| disorder | n/a | 487 | 489 |
| disorder | n/a | 491 | 492 |
| disorder | n/a | 495 | 496 |
| disorder | n/a | 507 | 509 |
| disorder | n/a | 511 | 516 |
| disorder | n/a | 522 | 526 |
| low_complexity | n/a | 525 | 542 |
| disorder | n/a | 529 | 551 |
| disorder | n/a | 559 | 592 |
| low_complexity | n/a | 562 | 581 |
| disorder | n/a | 595 | 658 |
| disorder | n/a | 661 | 663 |
| disorder | n/a | 678 | 689 |
| Pfam A | DUF3350 | 690 | 745 |
| disorder | n/a | 691 | 720 |
| coiled_coil | n/a | 734 | 757 |
| disorder | n/a | 744 | 748 |
| Pfam A | RabGAP-TBC | 803 | 1014 |
| disorder | n/a | 1075 | 1086 |
| coiled_coil | n/a | 1080 | 1149 |
| disorder | n/a | 1143 | 1168 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q86TI0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MEPITFTARK HLLSNEVSVD FGLQLVGSLP VHSLTTMPML PWVVAEVRRL
50 51
SRQSTRKEPV TKQVRLCVSP SGLRCEPEPG RSQQWDPLIY SSIFECKPQR
100 101
VHKLIHNSHD PSYFACLIKE DAVHRQSICY VFKADDQTKV PEIISSIRQA
150 151
GKIARQEELH CPSEFDDTFS KKFEVLFCGR VTVAHKKAPP ALIDECIEKF
200 201
NHVSGSRGSE SPRPNPPHAA PTGSQEPVRR PMRKSFSQPG LRSLAFRKEL
250 251
QDGGLRSSGF FSSFEESDIE NHLISGHNIV QPTDIEENRT MLFTIGQSEV
300 301
YLISPDTKKI ALEKNFKEIS FCSQGIRHVD HFGFICRESS GGGGFHFVCY
350 351
VFQCTNEALV DEIMMTLKQA FTVAAVQQTA KAPAQLCEGC PLQSLHKLCE
400 401
RIEGMNSSKT KLELQKHLTT LTNQEQATIF EEVQKLRPRN EQRENELIIS
450 451
FLRCLYEEKQ KEHIHIGEMK QTSQMAAENI GSELPPSATR FRLDMLKNKA
500 501
KRSLTESLES ILSRGNKARG LQEHSISVDL DSSLSSTLSN TSKEPSVCEK
550 551
EALPISESSF KLLGSSEDLS SDSESHLPEE PAPLSPQQAF RRRANTLSHF
600 601
PIECQEPPQP ARGSPGVSQR KLMRYHSVST ETPHERKDFE SKANHLGDSG
650 651
GTPVKTRRHS WRQQIFLRVA TPQKACDSSS RYEDYSELGE LPPRSPLEPV
700 701
CEDGPFGPPP EEKKRTSREL RELWQKAILQ QILLLRMEKE NQKLQASEND
750 751
LLNKRLKLDY EEITPCLKEV TTVWEKMLST PGRSKIKFDM EKMHSAVGQG
800 801
VPRHHRGEIW KFLAEQFHLK HQFPSKQQPK DVPYKELLKQ LTSQQHAILI
850 851
DLGRTFPTHP YFSAQLGAGQ LSLYNILKAY SLLDQEVGYC QGLSFVAGIL
900 901
LLHMSEEEAF KMLKFLMFDM GLRKQYRPDM IILQIQMYQL SRLLHDYHRD
950 951
LYNHLEEHEI GPSLYAAPWF LTMFASQFPL GFVARVFDMI FLQGTEVIFK
1000 1001
VALSLLGSHK PLILQHENLE TIVDFIKSTL PNLGLVQMEK TINQVFEMDI
1050 1051
AKQLQAYEVE YHVLQEELID SSPLSDNQRM DKLEKTNSSL RKQNLDLLEQ
1100 1101
LQVANGRIQS LEATIEKLLS SESKLKQAML TLELERSALL QTVEELRRRS
1150 1151
AEPSDREPEC TQPEPTGD
1168
Show the unformatted sequence. |
| Checksums: |
CRC64:5EFEA168F04C88E0
MD5:e0f494fb548d8b3fa02bb9cd0fface53
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| RabGAP-TBC | 803 - 1014 | 3QYE | A | 803 - 1014 | Jmol AstexViewer SPICE |
| B | 803 - 1014 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.