Summary
This is the summary of UniProt entry PK3CB_MOUSE (Q8BTI9).
| Description: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform EC=2.7.1.153 |
| Source organism: |
Mus musculus (Mouse)
(NCBI taxonomy ID
10090)
View Pfam proteome data. |
| Length: | 1064 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam A | PI3K_p85B | 35 | 112 |
| Pfam A | PI3K_rbd | 174 | 282 |
| low_complexity | n/a | 305 | 311 |
| Pfam A | PI3K_C2 | 341 | 486 |
| Pfam A | PI3Ka | 521 | 705 |
| low_complexity | n/a | 633 | 640 |
| Pfam A | PI3_PI4_kinase | 793 | 1011 |
| low_complexity | n/a | 802 | 820 |
| coiled_coil | n/a | 1025 | 1045 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q8BTI9. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MPPAMADNLD IWAVDSQIAS DGAISVDFLL PTGIYIQLEV PREATISYIK
50 51
QMLWKQVHNY PMFNLLMDID SYMFACVNQT AVYEELEDET RRLCDVRPFL
100 101
PVLKLVTRSC DPAEKLDSKI GVLIGKGLHE FDALKDPEVN EFRRKMRKFS
150 151
EAKIQSLVGL SWIDWLKHTY PPEHEPSVLE NLEDKLYGGK LVVAVHFENS
200 201
QDVFSFQVSP NLNPIKINEL AIQKRLTIRG KEDEASPCDY VLQVSGRVEY
250 251
VFGDHPLIQF QYIRNCVMNR TLPHFILVEC CKIKKMYEQE MIAIEAAINR
300 301
NSSNLPLPLP PKKTRVISHI WDNNNPFQIT LVKGNKLNTE ETVKVHVRAG
350 351
LFHGTELLCK TVVSSEISGK NDHIWNEQLE FDINICDLPR MARLCFAVYA
400 401
VLDKVKTKKS TKTINPSKYQ TIRKAGKVHY PVAWVNTMVF DFKGQLRSGD
450 451
VILHSWSSFP DELEEMLNPM GTVQTNPYAE NATALHITFP ENKKQPCYYP
500 501
PFDKIIEKAA ELASGDSANV SSRGGKKFLA VLKEILDRDP LSQLCENEMD
550 551
LIWTLRQDCR ENFPQSLPKL LLSIKWNKLE DVAQLQALLQ IWPKLPPREA
600 601
LELLDFNYPD QYVREYAVGC LRQMSDEELS QYLLQLVQVL KYEPFLDCAL
650 651
SRFLLERALD NRRIGQFLFW HLRSEVHTPA VSVQFGVILE AYCRGSVGHM
700 701
KVLSKQVEAL NKLKTLNSLI KLNAVKLSRA KGKEAMHTCL KQSAYREALS
750 751
DLQSPLNPCV ILSELYVEKC KYMDSKMKPL WLVYSSRAFG EDSVGVIFKN
800 801
GDDLRQDMLT LQMLRLMDLL WKEAGLDLRM LPYGCLATGD RSGLIEVVST
850 851
SETIADIQLN SSNVAATAAF NKDALLNWLK EYNSGDDLDR AIEEFTLSCA
900 901
GYCVASYVLG IGDRHSDNIM VKKTGQLFHI DFGHILGNFK SKFGIKRERV
950 951
PFILTYDFIH VIQQGKTGNT EKFGRFRQCC EDAYLILRRH GNLFITLFAL
1000 1001
MLTAGLPELT SVKDIQYLKD SLALGKSEEE ALKQFKQKFD EALRESWTTK
1050 1051
VNWMAHTVRK DYRS
1064
Show the unformatted sequence. |
| Checksums: |
CRC64:EBDF0266BF0A2032
MD5:4e34ac89e40bc81d874eb12842aaf65b
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| PI3_PI4_kinase | 793 - 1011 | 2Y3A | A | 793 - 1011 | Jmol AstexViewer SPICE |
| PI3K_C2 | 341 - 486 | 2Y3A | A | 341 - 486 | Jmol AstexViewer SPICE |
| PI3K_p85B | 35 - 112 | 2Y3A | A | 35 - 112 | Jmol AstexViewer SPICE |
| PI3K_rbd | 174 - 282 | 2Y3A | A | 174 - 282 | Jmol AstexViewer SPICE |
| PI3Ka | 525 - 705 | 2Y3A | A | 525 - 705 | Jmol AstexViewer SPICE |