Summary
This is the summary of UniProt entry ITCH_MOUSE (Q8C863).
| Description: | E3 ubiquitin-protein ligase Itchy EC=6.3.2.- |
| Source organism: |
Mus musculus (Mouse)
(NCBI taxonomy ID
10090)
View Pfam proteome data. |
| Length: | 864 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 10 |
| Pfam A | C2 | 20 | 99 |
| disorder | n/a | 48 | 61 |
| disorder | n/a | 64 | 65 |
| disorder | n/a | 117 | 144 |
| disorder | n/a | 148 | 328 |
| low_complexity | n/a | 195 | 206 |
| low_complexity | n/a | 209 | 226 |
| low_complexity | n/a | 230 | 259 |
| Pfam A | WW | 289 | 318 |
| Pfam A | WW | 321 | 350 |
| coiled_coil | n/a | 358 | 378 |
| disorder | n/a | 392 | 393 |
| disorder | n/a | 397 | 404 |
| Pfam A | WW | 401 | 430 |
| disorder | n/a | 427 | 439 |
| Pfam A | WW | 441 | 470 |
| disorder | n/a | 469 | 472 |
| Pfam A | HECT | 559 | 864 |
Show or hide domain scores.
Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
Note: it can take a few seconds for this image to be generated and loaded.
Show sources update panel.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q8C863. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MSDSGPQLDS MGSLTMKSQL QITVISAKLK ENKKNWFGPS PYVEVTVDGQ
50 51
SKKTEKCNNT NSPKWKQPLT VIVTPTSKLC FRVWSHQTLK SDVLLGTAGL
100 101
DIYETLKSNN MKLEEVVMTL QLVGDKEPTE TMGDLSVCLD GLQVEAEVVT
150 151
NGETSCSEST TQNDDGCRTR DDTRVSTNGS EDPEVAASGE NKRANGNNSP
200 201
SLSNGGFKPS RPPRPSRPPP PTPRRPASVN GSPSTNSDSD GSSTGSLPPT
250 251
NTNVNTSTSE GATSGLIIPL TISGGSGPRP LNTVSQAPLP PGWEQRVDQH
300 301
GRVYYVDHVE KRTTWDRPEP LPPGWERRVD NMGRIYYVDH FTRTTTWQRP
350 351
TLESVRNYEQ WQLQRSQLQG AMQQFNQRFI YGNQDLFATS QNKEFDPLGP
400 401
LPPGWEKRTD SNGRVYFVNH NTRITQWEDP RSQGQLNEKP LPEGWEMRFT
450 451
VDGIPYFVDH NRRATTYIDP RTGKSALDNG PQIAYVRDFK AKVQYFRFWC
500 501
QQLAMPQHIK ITVTRKTLFE DSFQQIMSFS PQDLRRRLWV IFPGEEGLDY
550 551
GGVAREWFFL LSHEVLNPMY CLFEYAGKDN YCLQINPASY INPDHLKYFR
600 601
FIGRFIAMAL FHGKFIDTGF SLPFYKRILN KPVGLKDLES IDPEFYNSLI
650 651
WVKENNIEEC GLEMYFSVDK EILGEIKSHD LKPNGGNILV TEENKEEYIR
700 701
MVAEWRLSRG VEEQTQAFFE GFNEILPQQY LQYFDAKELE VLLCGMQEID
750 751
LNDWQRHAIY RHYTRTSKQI MWFWQFVKEI DNEKRMRLLQ FVTGTCRLPV
800 801
GGFADLMGSN GPQKFCIEKV GKENWLPRSH TCFNRLDLPP YKSYEQLKEK
850 851
LLFAIEETEG FGQE
864
Show the unformatted sequence. |
| Checksums: |
CRC64:905FDBE00A1EA7EA
MD5:9360bd432e021fa135ebaece3c5ff790
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| WW | 401 - 430 | 1YIU | A | 6 - 35 | Jmol AstexViewer SPICE |
| 2JO9 | A | 6 - 35 | Jmol AstexViewer SPICE | ||
| 2JOC | A | 6 - 35 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.