Summary
This is the summary of UniProt entry MLL5_HUMAN (Q8IZD2).
| Description: | Histone-lysine N-methyltransferase MLL5 EC=2.1.1.43 |
| Source organism: |
Homo sapiens (Human) |
| Length: | 1858 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 14 | 34 |
| low_complexity | n/a | 23 | 38 |
| low_complexity | n/a | 48 | 55 |
| disorder | n/a | 67 | 85 |
| low_complexity | n/a | 70 | 81 |
| disorder | n/a | 94 | 110 |
| low_complexity | n/a | 100 | 109 |
| Pfam A | PHD | 120 | 166 |
| disorder | n/a | 171 | 203 |
| disorder | n/a | 214 | 268 |
| disorder | n/a | 288 | 293 |
| disorder | n/a | 295 | 296 |
| disorder | n/a | 298 | 301 |
| disorder | n/a | 303 | 316 |
| disorder | n/a | 318 | 324 |
| disorder | n/a | 339 | 341 |
| Pfam A | SET | 342 | 447 |
| disorder | n/a | 472 | 476 |
| disorder | n/a | 479 | 715 |
| low_complexity | n/a | 490 | 503 |
| low_complexity | n/a | 569 | 582 |
| coiled_coil | n/a | 574 | 611 |
| low_complexity | n/a | 698 | 716 |
| disorder | n/a | 719 | 726 |
| Pfam B | Pfam-B_7713 | 731 | 869 |
| disorder | n/a | 733 | 767 |
| disorder | n/a | 770 | 772 |
| disorder | n/a | 796 | 799 |
| disorder | n/a | 801 | 812 |
| disorder | n/a | 815 | 817 |
| disorder | n/a | 831 | 861 |
| Pfam B | Pfam-B_22469 | 871 | 959 |
| disorder | n/a | 882 | 883 |
| low_complexity | n/a | 882 | 901 |
| disorder | n/a | 887 | 919 |
| disorder | n/a | 921 | 988 |
| low_complexity | n/a | 933 | 945 |
| low_complexity | n/a | 951 | 960 |
| Pfam B | Pfam-B_20626 | 961 | 1129 |
| disorder | n/a | 990 | 1068 |
| disorder | n/a | 1078 | 1087 |
| disorder | n/a | 1089 | 1094 |
| Pfam B | Pfam-B_19601 | 1131 | 1179 |
| disorder | n/a | 1140 | 1188 |
| disorder | n/a | 1190 | 1858 |
| Pfam B | Pfam-B_24586 | 1261 | 1299 |
| low_complexity | n/a | 1285 | 1303 |
| Pfam B | Pfam-B_19470 | 1301 | 1369 |
| low_complexity | n/a | 1323 | 1337 |
| low_complexity | n/a | 1349 | 1362 |
| low_complexity | n/a | 1544 | 1555 |
| low_complexity | n/a | 1622 | 1636 |
| Pfam B | Pfam-B_7010 | 1651 | 1789 |
| low_complexity | n/a | 1675 | 1696 |
| low_complexity | n/a | 1715 | 1723 |
| Pfam B | Pfam-B_13611 | 1791 | 1856 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q8IZD2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MSIVIPLGVD TAETSYLEMA AGSEPESVEA SPVVVEKSNS YPHQLYTSSS
50 51
HHSHSYIGLP YADHNYGARP PPTPPASPPP SVLISKNEVG IFTTPNFDET
100 101
SSATTISTSE DGSYGTDVTR CICGFTHDDG YMICCDKCSV WQHIDCMGID
150 151
RQHIPDTYLC ERCQPRNLDK ERAVLLQRRK RENMSDGDTS ATESGDEVPV
200 201
ELYTAFQHTP TSITLTASRV SKVNDKRRKK SGEKEQHISK CKKAFREGSR
250 251
KSSRVKGSAP EIDPSSDGSN FGWETKIKAW MDRYEEANNN QYSEGVQREA
300 301
QRIALRLGNG NDKKEMNKSD LNTNNLLFKP PVESHIQKNK KILKSAKDLP
350 351
PDALIIEYRG KFMLREQFEA NGYFFKRPYP FVLFYSKFHG LEMCVDARTF
400 401
GNEARFIRRS CTPNAEVRHE IQDGTIHLYI YSIHSIPKGT EITIAFDFDY
450 451
GNCKYKVDCA CLKENPECPV LKRSSESMEN INSGYETRRK KGKKDKDISK
500 501
EKDTQNQNIT LDCEGTTNKM KSPETKQRKL SPLRLSVSNN QEPDFIDDIE
550 551
EKTPISNEVE MESEEQIAER KRKMTREERK MEAILQAFAR LEKREKRREQ
600 601
ALERISTAKT EVKTECKDTQ IVSDAEVIQE QAKEENASKP TPAKVNRTKQ
650 651
RKSFSRSRTH IGQQRRRHRT VSMCSDIQPS SPDIEVTSQQ NDIENTVLTI
700 701
EPETETALAE IITETEVPAL NKCPTKYPKT KKHLVNEWLS EKNEKTGKPS
750 751
DGLSERPLRI TTDPEVLATQ LNSLPGLTYS PHVYSTPKHY IRFTSPFLSE
800 801
KRRRKEPTEN ISGSCKKRWL KQALEEENSA ILHRFNSPCQ ERSRSPAVNG
850 851
ENKSPLLLND SCSLPDLTTP LKKRRFYQLL DSVYSETSTP TPSPYATPTH
900 901
TDITPMDPSF ATPPRIKSDD ETCRNGYKPI YSPVTPVTPG TPGNTMHFEN
950 951
ISSPESSPEI KRRTYSQEGY DRSSTMLTLG PFRNSNLTEL GLQEIKTIGY
1000 1001
TSPRSRTEVN RQCPGEKEPV SDLQLGLDAV EPTALHKTLE TPAHDRAEPN
1050 1051
SQLDSTHSGR GTMYSSWVKS PDRTGVNFSV NSNLRDLTPS HQLEVGGGFR
1100 1101
ISESKCLMQD DTRGMFMETT VFCTSEDGLV SGFGRTVNDN LIDGNCTPQN
1150 1151
PPQKKKVSLL EYRKRQREAR KSGSKTENFP LISVSPHASG SLSNNGDGCA
1200 1201
SSNDNGEQVD HTASLPLPTP ATVYNATSEE TSNNCPVKDA TASEKNEPEV
1250 1251
QWTASTSVEQ VRERSYQRAL LLSDHRKDKD SGGESPCVSC SPSHVQSSPS
1300 1301
SHSNHIPQLQ AKGPVPSFSE LMEDPDPENP EPTTTNECPS PDTSQNTCKS
1350 1351
PPKMSKPGSP GSVIPAQAHG KIFTKPDPQW DSTVSASEAE NGVHLKTELQ
1400 1401
QKQLSNNNQA LSKNHPPQTH VRNSSEQLSQ KLPSVPTKLH CPPSPHLENP
1450 1451
PKSSTPHTPV QHGYLSPKPP SQQLGSPYRP HHSQSPQVGT PQREPQRNFY
1500 1501
PAAQNLPANT QQATSGTLFT QTPSGQSSAT YSQFNQQSLN STAPPPPPPP
1550 1551
PPSSSYYQNQ QPSANFQNYN QLKGSLSQQT VFTSGPNQAL PGTTSQQTVP
1600 1601
GHHVTPGHFL PSQNPTIHHQ TAAAVVPPPP PPPPAPGPHL VQQPNSHQQH
1650 1651
SVAHVVGPVH AVTPGSHIHS QTAGHHLPPP PPPPGPAPHH HPPPHPSTGL
1700 1701
QGLQAQHQHV VNSAPPPPPP PPPSSVLASG HHTTSAQALH HPPHQGPPLF
1750 1751
PSSAHPTVPP YPSQATHHTT LGPGPQHQPS GTGPHCPLPV TGPHLQPQGP
1800 1801
NSIPTPTASG FCPHPGSVAL PHGVQGPQQA SPVPGQIPIH RAQVPPTFQN
1850 1851
NYHGSGWH
1858
Show the unformatted sequence. |
| Checksums: |
CRC64:8ACCB3CDB5BFCEFA
MD5:480bc2896a6dcdbb94f926281039f8fe
|
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.