Summary
This is the summary of UniProt entry PK3C3_HUMAN (Q8NEB9).
| Description: | Phosphatidylinositol 3-kinase catalytic subunit type 3 EC=2.7.1.137 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 887 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam A | PI3K_C2 | 53 | 198 |
| disorder | n/a | 147 | 170 |
| disorder | n/a | 173 | 175 |
| disorder | n/a | 264 | 265 |
| disorder | n/a | 273 | 274 |
| disorder | n/a | 277 | 288 |
| Pfam A | PI3Ka | 284 | 530 |
| low_complexity | n/a | 392 | 403 |
| disorder | n/a | 416 | 433 |
| low_complexity | n/a | 422 | 437 |
| disorder | n/a | 446 | 467 |
| low_complexity | n/a | 448 | 460 |
| disorder | n/a | 508 | 516 |
| disorder | n/a | 569 | 573 |
| Pfam A | PI3_PI4_kinase | 630 | 833 |
| low_complexity | n/a | 770 | 779 |
| disorder | n/a | 776 | 786 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q8NEB9. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MGEAEKFHYI YSCDLDINVQ LKIGSLEGKR EQKSYKAVLE DPMLKFSGLY
50 51
QETCSDLYVT CQVFAEGKPL ALPVRTSYKA FSTRWNWNEW LKLPVKYPDL
100 101
PRNAQVALTI WDVYGPGKAV PVGGTTVSLF GKYGMFRQGM HDLKVWPNVE
150 151
ADGSEPTKTP GRTSSTLSED QMSRLAKLTK AHRQGHMVKV DWLDRLTFRE
200 201
IEMINESEKR SSNFMYLMVE FRCVKCDDKE YGIVYYEKDG DESSPILTSF
250 251
ELVKVPDPQM SMENLVESKH HKLARSLRSG PSDHDLKPNA ATRDQLNIIV
300 301
SYPPTKQLTY EEQDLVWKFR YYLTNQEKAL TKFLKCVNWD LPQEAKQALE
350 351
LLGKWKPMDV EDSLELLSSH YTNPTVRRYA VARLRQADDE DLLMYLLQLV
400 401
QALKYENFDD IKNGLEPTKK DSQSSVSENV SNSGINSAEI DSSQIITSPL
450 451
PSVSSPPPAS KTKEVPDGEN LEQDLCTFLI SRACKNSTLA NYLYWYVIVE
500 501
CEDQDTQQRD PKTHEMYLNV MRRFSQALLK GDKSVRVMRS LLAAQQTFVD
550 551
RLVHLMKAVQ RESGNRKKKN ERLQALLGDN EKMNLSDVEL IPLPLEPQVK
600 601
IRGIIPETAT LFKSALMPAQ LFFKTEDGGK YPVIFKHGDD LRQDQLILQI
650 651
ISLMDKLLRK ENLDLKLTPY KVLATSTKHG FMQFIQSVPV AEVLDTEGSI
700 701
QNFFRKYAPS ENGPNGISAE VMDTYVKSCA GYCVITYILG VGDRHLDNLL
750 751
LTKTGKLFHI DFGYILGRDP KPLPPPMKLN KEMVEGMGGT QSEQYQEFRK
800 801
QCYTAFLHLR RYSNLILNLF SLMVDANIPD IALEPDKTVK KVQDKFRLDL
850 851
SDEEAVHYMQ SLIDESVHAL FAAVVEQIHK FAQYWRK
887
Show the unformatted sequence. |
| Checksums: |
CRC64:1C03D97338E44976
MD5:f32641961d1be377ede4b0a5e9e9a157
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| PI3_PI4_kinase | 630 - 833 | 3IHY | A | 630 - 833 | Jmol AstexViewer SPICE |
| B | 630 - 833 | Jmol AstexViewer SPICE | |||
| C | 630 - 833 | Jmol AstexViewer SPICE | |||
| D | 630 - 833 | Jmol AstexViewer SPICE | |||
| E | 630 - 833 | Jmol AstexViewer SPICE | |||
| 3LS8 | A | 630 - 833 | Jmol AstexViewer SPICE | ||
| B | 630 - 833 | Jmol AstexViewer SPICE | |||
| PI3Ka | 284 - 530 | 3IHY | A | 284 - 530 | Jmol AstexViewer SPICE |
| B | 284 - 530 | Jmol AstexViewer SPICE | |||
| C | 284 - 530 | Jmol AstexViewer SPICE | |||
| E | 284 - 530 | Jmol AstexViewer SPICE | |||
| 3LS8 | A | 284 - 530 | Jmol AstexViewer SPICE | ||
| 286 - 530 | 3IHY | D | 286 - 530 | Jmol AstexViewer SPICE | |
| 296 - 530 | 3LS8 | B | 296 - 530 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.