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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: NEIL1_HUMAN (Q96FI4)

Summary

This is the summary of UniProt entry NEIL1_HUMAN (Q96FI4).

Description: Endonuclease 8-like 1 EC=3.2.2.- EC=4.2.99.18
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 390 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A Fapy_DNA_glyco 2 124
Pfam A H2TH 134 221
disorder n/a 211 214
disorder n/a 240 241
low_complexity n/a 240 251
Pfam A Neil1-DNA_bind 252 290
disorder n/a 273 390
low_complexity n/a 291 301

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q96FI4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPEGPELHLA SQFVNEACRA LVFGGCVEKS SVSRNPEVPF ESSAYRISAS
50
51
ARGKELRLIL SPLPGAQPQQ EPLALVFRFG MSGSFQLVPR EELPRHAHLR
100
101
FYTAPPGPRL ALCFVDIRRF GRWDLGGKWQ PGRGPCVLQE YQQFRENVLR
150
151
NLADKAFDRP ICEALLDQRF FNGIGNYLRA EILYRLKIPP FEKARSVLEA
200
201
LQQHRPSPEL TLSQKIRTKL QNPDLLELCH SVPKEVVQLG GKGYGSESGE
250
251
EDFAAFRAWL RCYGMPGMSS LQDRHGRTIW FQGDPGPLAP KGRKSRKKKS
300
301
KATQLSPEDR VEDALPPSKA PSRTRRAKRD LPKRTATQRP EGTSLQQDPE
350
351
APTVPKKGRR KGRQAASGHC RPRKVKADIP SLEPEGTSAS           
390
 

Show the unformatted sequence.

Checksums:
CRC64:B2B058486C4EF835
MD5:fd380fe00b72f8ea55514236833e896a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Fapy_DNA_glyco 2 - 124 1TDH A 2 - 124 Jmol AstexViewer SPICE
H2TH 134 - 221 1TDH A 134 - 221 Jmol AstexViewer SPICE
Neil1-DNA_bind 252 - 290 1TDH A 252 - 290 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.