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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: DOK1_HUMAN (Q99704)

Summary

This is the summary of UniProt entry DOK1_HUMAN (Q99704).

Description: Docking protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 481 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
low_complexity n/a 47 59
low_complexity n/a 73 88
disorder n/a 82 89
Pfam A IRS 151 254
disorder n/a 228 230
disorder n/a 252 294
disorder n/a 300 302
disorder n/a 307 330
disorder n/a 335 337
disorder n/a 348 377
disorder n/a 399 453
disorder n/a 459 481

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q99704. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDGAVMEGPL FLQSQRFGTK RWRKTWAVLY PASPHGVARL EFFDHKGSSS
50
51
GGGRGSSRRL DCKVIRLAEC VSVAPVTVET PPEPGATAFR LDTAQRSHLL
100
101
AADAPSSAAW VQTLCRNAFP KGSWTLAPTD NPPKLSALEM LENSLYSPTW
150
151
EGSQFWVTVQ RTEAAERCGL HGSYVLRVEA ERLTLLTVGA QSQILEPLLS
200
201
WPYTLLRRYG RDKVMFSFEA GRRCPSGPGT FTFQTAQGND IFQAVETAIH
250
251
RQKAQGKAGQ GHDVLRADSH EGEVAEGKLP SPPGPQELLD SPPALYAEPL
300
301
DSLRIAPCPS QDSLYSDPLD STSAQAGEGV QRKKPLYWDL YEHAQQQLLK
350
351
AKLTDPKEDP IYDEPEGLAP VPPQGLYDLP REPKDAWWCQ ARVKEEGYEL
400
401
PYNPATDDYA VPPPRSTKPL LAPKPQGPAF PEPGTATGSG IKSHNSALYS
450
451
QVQKSGASGS WDCGLSRVGT DKTGVKSEGS T                    
481
 

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Checksums:
CRC64:E9D947831244BA6C
MD5:873dd3e747fbf75dac621b146b6dd86e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
IRS 152 - 252 2V76 A 4 - 104 Jmol AstexViewer SPICE
153 - 251 2V76 D 5 - 103 Jmol AstexViewer SPICE
153 - 254 2V76 B 5 - 106 Jmol AstexViewer SPICE
C 5 - 106 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.