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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: FOXC2_HUMAN (Q99958)

Summary

This is the summary of UniProt entry FOXC2_HUMAN (Q99958).

Description: Forkhead box protein C2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 501 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A Fork_head 72 167
disorder n/a 131 133
disorder n/a 141 144
low_complexity n/a 163 167
disorder n/a 167 214
Pfam B Pfam-B_66367 212 324
disorder n/a 223 293
low_complexity n/a 294 314
disorder n/a 316 319
disorder n/a 344 423
low_complexity n/a 383 422
Pfam B Pfam-B_22728 387 499
disorder n/a 427 428
disorder n/a 433 480

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q99958. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MQARYSVSDP NALGVVPYLS EQNYYRAAGS YGGMASPMGV YSGHPEQYSA
50
51
GMGRSYAPYH HHQPAAPKDL VKPPYSYIAL ITMAIQNAPE KKITLNGIYQ
100
101
FIMDRFPFYR ENKQGWQNSI RHNLSLNECF VKVPRDDKKP GKGSYWTLDP
150
151
DSYNMFENGS FLRRRRRFKK KDVSKEKEER AHLKEPPPAA SKGAPATPHL
200
201
ADAPKEAEKK VVIKSEAASP ALPVITKVET LSPESALQGS PRSAASTPAG
250
251
SPDGSLPEHH AAAPNGLPGF SVENIMTLRT SPPGGELSPG AGRAGLVVPP
300
301
LALPYAAAPP AAYGQPCAQG LEAGAAGGYQ CSMRAMSLYT GAERPAHMCV
350
351
PPALDEALSD HPSGPTSPLS ALNLAAGQEG ALAATGHHHQ HHGHHHPQAP
400
401
PPPPAPQPQP TPQPGAAAAQ AASWYLNHSG DLNHLPGHTF AAQQQTFPNV
450
451
REMFNSHRLG IENSTLGESQ VSGNASCQLP YRSTPPLYRH AAPYSYDCTK
500
501
Y                                                     
501
 

Show the unformatted sequence.

Checksums:
CRC64:F66513878EDC3A87
MD5:c64390fa64351184058a70975ff15c6a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Fork_head 72 - 162 1D5V A 4 - 94 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.