Summary
This is the summary of UniProt entry GRIP2_HUMAN (Q9C0E4).
| Description: | Glutamate receptor-interacting protein 2 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 1043 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 3 | 22 |
| Pfam A | PDZ | 48 | 128 |
| low_complexity | n/a | 56 | 67 |
| disorder | n/a | 62 | 78 |
| disorder | n/a | 127 | 131 |
| disorder | n/a | 135 | 140 |
| disorder | n/a | 142 | 143 |
| Pfam A | PDZ | 147 | 231 |
| disorder | n/a | 163 | 164 |
| disorder | n/a | 173 | 181 |
| disorder | n/a | 192 | 193 |
| Pfam A | PDZ | 249 | 329 |
| disorder | n/a | 295 | 296 |
| disorder | n/a | 328 | 347 |
| disorder | n/a | 349 | 350 |
| disorder | n/a | 355 | 358 |
| disorder | n/a | 366 | 391 |
| low_complexity | n/a | 384 | 397 |
| disorder | n/a | 399 | 401 |
| disorder | n/a | 403 | 448 |
| low_complexity | n/a | 424 | 430 |
| disorder | n/a | 454 | 455 |
| Pfam A | PDZ | 456 | 542 |
| Pfam A | PDZ | 557 | 638 |
| Pfam A | PDZ | 656 | 735 |
| disorder | n/a | 736 | 738 |
| disorder | n/a | 741 | 873 |
| low_complexity | n/a | 839 | 856 |
| disorder | n/a | 875 | 876 |
| disorder | n/a | 881 | 897 |
| disorder | n/a | 899 | 945 |
| low_complexity | n/a | 927 | 939 |
| Pfam A | PDZ | 941 | 1020 |
| disorder | n/a | 968 | 970 |
| disorder | n/a | 972 | 987 |
| disorder | n/a | 1021 | 1043 |
| low_complexity | n/a | 1028 | 1041 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9C0E4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MLCGLSRETP GEADDGPYSK GGKDAGGADV SLACRRQSIP EEFRGITVVE
50 51
LIKKEGSTLG LTISGGTDKD GKPRVSNLRP GGLAARSDLL NIGDYIRSVN
100 101
GIHLTRLRHD EIITLLKNVG ERVVLEVEYE LPPPAPENNP RIISKTVDVS
150 151
LYKEGNSFGF VLRGGAHEDG HKSRPLVLTY VRPGGPADRE GSLKVGDRLL
200 201
SVDGIPLHGA SHATALATLR QCSHEALFQV EYDVATPDTV ANASGPLMVE
250 251
IVKTPGSALG ISLTTTSLRN KSVITIDRIK PASVVDRSGA LHPGDHILSI
300 301
DGTSMEHCSL LEATKLLASI SEKVRLEILP VPQSQRPLRP SEAVKVQRSE
350 351
QLHRWDPCVP SCHSPRPGHC RMPTWATPAG QDQSRSLSST PFSSPTLNHA
400 401
FSCNNPSTLP RGSQPMSPRT TMGRRRQRRR EHKSSLSLAS STVGPGGQIV
450 451
HTETTEVVLC GDPLSGFGLQ LQGGIFATET LSSPPLVCFI EPDSPAERCG
500 501
LLQVGDRVLS INGIATEDGT MEEANQLLRD AALAHKVVLE VEFDVAESVI
550 551
PSSGTFHVKL PKKRSVELGI TISSASRKRG EPLIISDIKK GSVAHRTGTL
600 601
EPGDKLLAID NIRLDNCPME DAVQILRQCE DLVKLKIRKD EDNSDELETT
650 651
GAVSYTVELK RYGGPLGITI SGTEEPFDPI VISGLTKRGL AERTGAIHVG
700 701
DRILAINNVS LKGRPLSEAI HLLQVAGETV TLKIKKQLDR PLLPRKSGSL
750 751
SETSDADEDP ADALKGGLPA ARFSPAVPSV DSAVESWDSS ATEGGFGGPG
800 801
SYTPQAAARG TTPQERRPGW LRGSPPPTEP RRTSYTPTPA DESFPEEEEG
850 851
DDWEPPTSPA PGPAREEGFW RMFGEALEDL ESCGQSELLR ELEASIMTGT
900 901
VQRVALEGRP GHRPWQRGRE VRASPAEMEE LLLPTPLEMH KVTLHKDPMR
950 951
HDFGFSVSDG LLEKGVYVHT VRPDGPAHRG GLQPFDRVLQ VNHVRTRDFD
1000 1001
CCLAVPLLAE AGDVLELIIS RKPHTAHSSR APRSPGPSSP RML
1043
Show the unformatted sequence. |
| Checksums: |
CRC64:26E384310D706B1F
MD5:81c00a0cee2ac76fad08e526113a1f71
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| PDZ | 249 - 329 | 1V62 | A | 19 - 99 | Jmol AstexViewer SPICE |
| 456 - 542 | 1X5R | A | 18 - 104 | Jmol AstexViewer SPICE |