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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: PTN23_HUMAN (Q9H3S7)

Summary

This is the summary of UniProt entry PTN23_HUMAN (Q9H3S7).

Description: Tyrosine-protein phosphatase non-receptor type 23 EC=3.1.3.48
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1636 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A BRO1 8 384
disorder n/a 338 339
disorder n/a 341 345
disorder n/a 398 399
disorder n/a 408 409
Pfam A ALIX_LYPXL_bnd 411 704
low_complexity n/a 461 470
disorder n/a 539 540
coiled_coil n/a 556 583
disorder n/a 693 695
disorder n/a 698 1179
low_complexity n/a 712 730
low_complexity n/a 767 785
Pfam B Pfam-B_8360 781 829
low_complexity n/a 814 829
Pfam B Pfam-B_25413 831 889
low_complexity n/a 842 866
Pfam B Pfam-B_38949 891 929
low_complexity n/a 897 925
low_complexity n/a 953 963
low_complexity n/a 965 989
low_complexity n/a 993 1014
low_complexity n/a 1031 1056
low_complexity n/a 1080 1108
disorder n/a 1192 1194
disorder n/a 1196 1199
Pfam A Y_phosphatase 1217 1451
disorder n/a 1230 1231
disorder n/a 1299 1300
disorder n/a 1420 1424
disorder n/a 1460 1462
disorder n/a 1464 1491
disorder n/a 1500 1501
disorder n/a 1504 1632
low_complexity n/a 1518 1587
low_complexity n/a 1619 1630

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9H3S7. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEAVPRMPMI WLDLKEAGDF HFQPAVKKFV LKNYGENPEA YNEELKKLEL
50
51
LRQNAVRVPR DFEGCSVLRK YLGQLHYLQS RVPMGSGQEA AVPVTWTEIF
100
101
SGKSVAHEDI KYEQACILYN LGALHSMLGA MDKRVSEEGM KVSCTHFQCA
150
151
AGAFAYLREH FPQAYSVDMS RQILTLNVNL MLGQAQECLL EKSMLDNRKS
200
201
FLVARISAQV VDYYKEACRA LENPDTASLL GRIQKDWKKL VQMKIYYFAA
250
251
VAHLHMGKQA EEQQKFGERV AYFQSALDKL NEAIKLAKGQ PDTVQDALRF
300
301
TMDVIGGKYN SAKKDNDFIY HEAVPALDTL QPVKGAPLVK PLPVNPTDPA
350
351
VTGPDIFAKL VPMAAHEASS LYSEEKAKLL REMMAKIEDK NEVLDQFMDS
400
401
MQLDPETVDN LDAYSHIPPQ LMEKCAALSV RPDTVRNLVQ SMQVLSGVFT
450
451
DVEASLKDIR DLLEEDELLE QKFQEAVGQA GAISITSKAE LAEVRREWAK
500
501
YMEVHEKASF TNSELHRAMN LHVGNLRLLS GPLDQVRAAL PTPALSPEDK
550
551
AVLQNLKRIL AKVQEMRDQR VSLEQQLREL IQKDDITASL VTTDHSEMKK
600
601
LFEEQLKKYD QLKVYLEQNL AAQDRVLCAL TEANVQYAAV RRVLSDLDQK
650
651
WNSTLQTLVA SYEAYEDLMK KSQEGRDFYA DLESKVAALL ERTQSTCQAR
700
701
EAARQQLLDR ELKKKPPPRP TAPKPLLPRR EESEAVEAGD PPEELRSLPP
750
751
DMVAGPRLPD TFLGSATPLH FPPSPFPSST GPGPHYLSGP LPPGTYSGPT
800
801
QLIQPRAPGP HAMPVAPGPA LYPAPAYTPE LGLVPRSSPQ HGVVSSPYVG
850
851
VGPAPPVAGL PSAPPPQFSG PELAMAVRPA TTTVDSIQAP IPSHTAPRPN
900
901
PTPAPPPPCF PVPPPQPLPT PYTYPAGAKQ PIPAQHHFSS GIPAGFPAPR
950
951
IGPQPQPHPQ PHPSQAFGPQ PPQQPLPLQH PHLFPPQAPG LLPPQSPYPY
1000
1001
APQPGVLGQP PPPLHTQLYP GPAQDPLPAH SGALPFPSPG PPQPPHPPLA
1050
1051
YGPAPSTRPM GPQAAPLTIR GPSSAGQSTP SPHLVPSPAP SPGPGPVPPR
1100
1101
PPAAEPPPCL RRGAAAADLL SSSPESQHGG TQSPGGGQPL LQPTKVDAAE
1150
1151
GRRPQALRLI ERDPYEHPER LRQLQQELEA FRGQLGDVGA LDTVWRELQD
1200
1201
AQEHDARGRS IAIARCYSLK NRHQDVMPYD SNRVVLRSGK DDYINASCVE
1250
1251
GLSPYCPPLV ATQAPLPGTA ADFWLMVHEQ KVSVIVMLVS EAEMEKQKVA
1300
1301
RYFPTERGQP MVHGALSLAL SSVRSTETHV ERVLSLQFRD QSLKRSLVHL
1350
1351
HFPTWPELGL PDSPSNLLRF IQEVHAHYLH QRPLHTPIIV HCSSGVGRTG
1400
1401
AFALLYAAVQ EVEAGNGIPE LPQLVRRMRQ QRKHMLQEKL HLRFCYEAVV
1450
1451
RHVEQVLQRH GVPPPCKPLA SASISQKNHL PQDSQDLVLG GDVPISSIQA
1500
1501
TIAKLSIRPP GGLESPVASL PGPAEPPGLP PASLPESTPI PSSSPPPLSS
1550
1551
PLPEAPQPKE EPPVPEAPSS GPPSSSLELL ASLTPEAFSL DSSLRGKQRM
1600
1601
SKHNFLQAHN GQGLRATRPS DDPLSLLDPL WTLNKT               
1636
 

Show the unformatted sequence.

Checksums:
CRC64:536BDDF9D3DC95C0
MD5:8f53e379afb90f19b6c860b1c1a371f3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
BRO1 8 - 361 3RAU A 8 - 361 Jmol AstexViewer SPICE
B 8 - 361 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.