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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CDK12_HUMAN (Q9NYV4)

Summary

This is the summary of UniProt entry CDK12_HUMAN (Q9NYV4).

Description: Cyclin-dependent kinase 12 EC=2.7.11.22 EC=2.7.11.23
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1490 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 1 79
low_complexity n/a 8 19
low_complexity n/a 24 32
low_complexity n/a 40 51
low_complexity n/a 74 86
disorder n/a 82 707
low_complexity n/a 107 120
low_complexity n/a 126 144
low_complexity n/a 168 183
low_complexity n/a 215 228
low_complexity n/a 287 385
low_complexity n/a 407 413
low_complexity n/a 514 571
low_complexity n/a 577 593
low_complexity n/a 601 616
Pfam B Pfam-B_42967 611 679
low_complexity n/a 627 637
low_complexity n/a 665 684
disorder n/a 709 711
Pfam A Pkinase 727 1020
disorder n/a 1020 1021
disorder n/a 1037 1042
disorder n/a 1050 1107
disorder n/a 1131 1371
coiled_coil n/a 1143 1163
low_complexity n/a 1256 1280
disorder n/a 1373 1385
low_complexity n/a 1377 1388
disorder n/a 1387 1403
disorder n/a 1416 1419
disorder n/a 1421 1429
disorder n/a 1431 1460
low_complexity n/a 1446 1456
disorder n/a 1464 1466
disorder n/a 1468 1490
low_complexity n/a 1473 1489

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9NYV4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPNSERHGGK KDGSGGASGT LQPSSGGGSS NSRERHRLVS KHKRHKSKHS
50
51
KDMGLVTPEA ASLGTVIKPL VEYDDISSDS DTFSDDMAFK LDRRENDERR
100
101
GSDRSDRLHK HRHHQHRRSR DLLKAKQTEK EKSQEVSSKS GSMKDRISGS
150
151
SKRSNEETDD YGKAQVAKSS SKESRSSKLH KEKTRKEREL KSGHKDRSKS
200
201
HRKRETPKSY KTVDSPKRRS RSPHRKWSDS SKQDDSPSGA SYGQDYDLSP
250
251
SRSHTSSNYD SYKKSPGSTS RRQSVSPPYK EPSAYQSSTR SPSPYSRRQR
300
301
SVSPYSRRRS SSYERSGSYS GRSPSPYGRR RSSSPFLSKR SLSRSPLPSR
350
351
KSMKSRSRSP AYSRHSSSHS KKKRSSSRSR HSSISPVRLP LNSSLGAELS
400
401
RKKKERAAAA AAAKMDGKES KGSPVFLPRK ENSSVEAKDS GLESKKLPRS
450
451
VKLEKSAPDT ELVNVTHLNT EVKNSSDTGK VKLDENSEKH LVKDLKAQGT
500
501
RDSKPIALKE EIVTPKETET SEKETPPPLP TIASPPPPLP TTTPPPQTPP
550
551
LPPLPPIPAL PQQPPLPPSQ PAFSQVPASS TSTLPPSTHS KTSAVSSQAN
600
601
SQPPVQVSVK TQVSVTAAIP HLKTSTLPPL PLPPLLPGDD DMDSPKETLP
650
651
SKPVKKEKEQ RTRHLLTDLP LPPELPGGDL SPPDSPEPKA ITPPQQPYKK
700
701
RPKICCPRYG ERRQTESDWG KRCVDKFDII GIIGEGTYGQ VYKAKDKDTG
750
751
ELVALKKVRL DNEKEGFPIT AIREIKILRQ LIHRSVVNMK EIVTDKQDAL
800
801
DFKKDKGAFY LVFEYMDHDL MGLLESGLVH FSEDHIKSFM KQLMEGLEYC
850
851
HKKNFLHRDI KCSNILLNNS GQIKLADFGL ARLYNSEESR PYTNKVITLW
900
901
YRPPELLLGE ERYTPAIDVW SCGCILGELF TKKPIFQANL ELAQLELISR
950
951
LCGSPCPAVW PDVIKLPYFN TMKPKKQYRR RLREEFSFIP SAALDLLDHM
1000
1001
LTLDPSKRCT AEQTLQSDFL KDVELSKMAP PDLPHWQDCH ELWSKKRRRQ
1050
1051
RQSGVVVEEP PPSKTSRKET TSGTSTEPVK NSSPAPPQPA PGKVESGAGD
1100
1101
AIGLADITQQ LNQSELAVLL NLLQSQTDLS IPQMAQLLNI HSNPEMQQQL
1150
1151
EALNQSISAL TEATSQQQDS ETMAPEESLK EAPSAPVILP SAEQTTLEAS
1200
1201
STPADMQNIL AVLLSQLMKT QEPAGSLEEN NSDKNSGPQG PRRTPTMPQE
1250
1251
EAAACPPHIL PPEKRPPEPP GPPPPPPPPP LVEGDLSSAP QELNPAVTAA
1300
1301
LLQLLSQPEA EPPGHLPHEH QALRPMEYST RPRPNRTYGN TDGPETGFSA
1350
1351
IDTDERNSGP ALTESLVQTL VKNRTFSGSL SHLGESSSYQ GTGSVQFPGD
1400
1401
QDLRFARVPL ALHPVVGQPF LKAEGSSNSV VHAETKLQNY GELGPGTTGA
1450
1451
SSSGAGLHWG GPTQSSAYGK LYRGPTRVPP RGGRGRGVPY           
1490
 

Show the unformatted sequence.

Checksums:
CRC64:D6B04B998ECDE58E
MD5:0a685d463d6798fbd30a3e3be74848e2