Summary
This is the summary of UniProt entry ADA22_HUMAN (Q9P0K1).
| Description: | Disintegrin and metalloproteinase domain-containing protein 22 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 906 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 25 |
| disorder | n/a | 31 | 32 |
| Pfam A | Pep_M12B_propep | 38 | 188 |
| disorder | n/a | 66 | 74 |
| disorder | n/a | 122 | 123 |
| disorder | n/a | 225 | 229 |
| Pfam A | Reprolysin | 239 | 438 |
| Pfam A | Disintegrin | 453 | 529 |
| Pfam A | ADAM_CR | 531 | 651 |
| low_complexity | n/a | 729 | 757 |
| transmembrane | n/a | 737 | 760 |
| disorder | n/a | 769 | 776 |
| disorder | n/a | 785 | 813 |
| low_complexity | n/a | 793 | 810 |
| disorder | n/a | 818 | 905 |
| Pfam B | Pfam-B_9056 | 821 | 904 |
| low_complexity | n/a | 862 | 877 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9P0K1. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MQAAVAVSVP FLLLCVLGTC PPARCGQAGD ASLMELEKRK ENRFVERQSI
50 51
VPLRLIYRSG GEDESRHDAL DTRVRGDLGG PQLTHVDQAS FQVDAFGTSF
100 101
ILDVVLNHDL LSSEYIERHI EHGGKTVEVK GGEHCYYQGH IRGNPDSFVA
150 151
LSTCHGLHGM FYDGNHTYLI EPEENDTTQE DFHFHSVYKS RLFEFSLDDL
200 201
PSEFQQVNIT PSKFILKPRP KRSKRQLRRY PRNVEEETKY IELMIVNDHL
250 251
MFKKHRLSVV HTNTYAKSVV NMADLIYKDQ LKTRIVLVAM ETWATDNKFA
300 301
ISENPLITLR EFMKYRRDFI KEKSDAVHLF SGSQFESSRS GAAYIGGICS
350 351
LLKGGGVNEF GKTDLMAVTL AQSLAHNIGI ISDKRKLASG ECKCEDTWSG
400 401
CIMGDTGYYL PKKFTQCNIE EYHDFLNSGG GACLFNKPSK LLDPPECGNG
450 451
FIETGEECDC GTPAECVLEG AECCKKCTLT QDSQCSDGLC CKKCKFQPMG
500 501
TVCREAVNDC DIRETCSGNS SQCAPNIHKM DGYSCDGVQG ICFGGRCKTR
550 551
DRQCKYIWGQ KVTASDKYCY EKLNIEGTEK GNCGKDKDTW IQCNKRDVLC
600 601
GYLLCTNIGN IPRLGELDGE ITSTLVVQQG RTLNCSGGHV KLEEDVDLGY
650 651
VEDGTPCGPQ MMCLEHRCLP VASFNFSTCL SSKEGTICSG NGVCSNELKC
700 701
VCNRHWIGSD CNTYFPHNDD AKTGITLSGN GVAGTNIIIG IIAGTILVLA
750 751
LILGITAWGY KNYREQRQLP QGDYVKKPGD GDSFYSDIPP GVSTNSASSS
800 801
KKRSNGLSHS WSERIPDTKH ISDICENGRP RSNSWQGNLG GNKKKIRGKR
850 851
FRPRSNSTET LSPAKSPSSS TGSIASSRKY PYPMPPLPDE DKKVNRQSAR
900 901
LWETSI
906
Show the unformatted sequence. |
| Checksums: |
CRC64:265ECCD0FA6C088B
MD5:61fbbdb6819dc9ad32f58585e309a6eb
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| ADAM_CR | 531 - 651 | 3G5C | A | 531 - 651 | Jmol AstexViewer SPICE |
| B | 531 - 651 | Jmol AstexViewer SPICE | |||
| Disintegrin | 453 - 529 | 3G5C | A | 453 - 529 | Jmol AstexViewer SPICE |
| B | 453 - 529 | Jmol AstexViewer SPICE | |||
| Reprolysin | 239 - 438 | 3G5C | A | 239 - 438 | Jmol AstexViewer SPICE |
| B | 239 - 438 | Jmol AstexViewer SPICE |