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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: ADA22_HUMAN (Q9P0K1)

Summary

This is the summary of UniProt entry ADA22_HUMAN (Q9P0K1).

Description: Disintegrin and metalloproteinase domain-containing protein 22
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 906 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 25
disorder n/a 31 32
Pfam A Pep_M12B_propep 38 188
disorder n/a 66 74
disorder n/a 122 123
disorder n/a 225 229
Pfam A Reprolysin 239 438
Pfam A Disintegrin 453 529
Pfam A ADAM_CR 531 651
low_complexity n/a 729 757
transmembrane n/a 737 760
disorder n/a 769 776
disorder n/a 785 813
low_complexity n/a 793 810
disorder n/a 818 905
Pfam B Pfam-B_9056 821 904
low_complexity n/a 862 877

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9P0K1. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MQAAVAVSVP FLLLCVLGTC PPARCGQAGD ASLMELEKRK ENRFVERQSI
50
51
VPLRLIYRSG GEDESRHDAL DTRVRGDLGG PQLTHVDQAS FQVDAFGTSF
100
101
ILDVVLNHDL LSSEYIERHI EHGGKTVEVK GGEHCYYQGH IRGNPDSFVA
150
151
LSTCHGLHGM FYDGNHTYLI EPEENDTTQE DFHFHSVYKS RLFEFSLDDL
200
201
PSEFQQVNIT PSKFILKPRP KRSKRQLRRY PRNVEEETKY IELMIVNDHL
250
251
MFKKHRLSVV HTNTYAKSVV NMADLIYKDQ LKTRIVLVAM ETWATDNKFA
300
301
ISENPLITLR EFMKYRRDFI KEKSDAVHLF SGSQFESSRS GAAYIGGICS
350
351
LLKGGGVNEF GKTDLMAVTL AQSLAHNIGI ISDKRKLASG ECKCEDTWSG
400
401
CIMGDTGYYL PKKFTQCNIE EYHDFLNSGG GACLFNKPSK LLDPPECGNG
450
451
FIETGEECDC GTPAECVLEG AECCKKCTLT QDSQCSDGLC CKKCKFQPMG
500
501
TVCREAVNDC DIRETCSGNS SQCAPNIHKM DGYSCDGVQG ICFGGRCKTR
550
551
DRQCKYIWGQ KVTASDKYCY EKLNIEGTEK GNCGKDKDTW IQCNKRDVLC
600
601
GYLLCTNIGN IPRLGELDGE ITSTLVVQQG RTLNCSGGHV KLEEDVDLGY
650
651
VEDGTPCGPQ MMCLEHRCLP VASFNFSTCL SSKEGTICSG NGVCSNELKC
700
701
VCNRHWIGSD CNTYFPHNDD AKTGITLSGN GVAGTNIIIG IIAGTILVLA
750
751
LILGITAWGY KNYREQRQLP QGDYVKKPGD GDSFYSDIPP GVSTNSASSS
800
801
KKRSNGLSHS WSERIPDTKH ISDICENGRP RSNSWQGNLG GNKKKIRGKR
850
851
FRPRSNSTET LSPAKSPSSS TGSIASSRKY PYPMPPLPDE DKKVNRQSAR
900
901
LWETSI                                                
906
 

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Checksums:
CRC64:265ECCD0FA6C088B
MD5:61fbbdb6819dc9ad32f58585e309a6eb

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ADAM_CR 531 - 651 3G5C A 531 - 651 Jmol AstexViewer SPICE
B 531 - 651 Jmol AstexViewer SPICE
Disintegrin 453 - 529 3G5C A 453 - 529 Jmol AstexViewer SPICE
B 453 - 529 Jmol AstexViewer SPICE
Reprolysin 239 - 438 3G5C A 239 - 438 Jmol AstexViewer SPICE
B 239 - 438 Jmol AstexViewer SPICE