Summary
This is the summary of UniProt entry TLR4_MOUSE (Q9QUK6).
| Description: | Toll-like receptor 4 |
| Source organism: |
Mus musculus (Mouse)
(NCBI taxonomy ID
10090)
View Pfam proteome data. |
| Length: | 835 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 25 |
| Pfam A | LRR_8 | 53 | 113 |
| Pfam A | LRR_8 | 89 | 137 |
| Pfam B | Pfam-B_23202 | 170 | 297 |
| Pfam A | LRR_6 | 370 | 395 |
| Pfam A | LRR_8 | 494 | 554 |
| low_complexity | n/a | 630 | 645 |
| transmembrane | n/a | 631 | 654 |
| Pfam A | TIR | 674 | 812 |
| disorder | n/a | 820 | 822 |
| low_complexity | n/a | 822 | 833 |
| disorder | n/a | 824 | 835 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9QUK6. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MMPPWLLART LIMALFFSCL TPGSLNPCIE VVPNITYQCM DQKLSKVPDD
50 51
IPSSTKNIDL SFNPLKILKS YSFSNFSELQ WLDLSRCEIE TIEDKAWHGL
100 101
HHLSNLILTG NPIQSFSPGS FSGLTSLENL VAVETKLASL ESFPIGQLIT
150 151
LKKLNVAHNF IHSCKLPAYF SNLTNLVHVD LSYNYIQTIT VNDLQFLREN
200 201
PQVNLSLDMS LNPIDFIQDQ AFQGIKLHEL TLRGNFNSSN IMKTCLQNLA
250 251
GLHVHRLILG EFKDERNLEI FEPSIMEGLC DVTIDEFRLT YTNDFSDDIV
300 301
KFHCLANVSA MSLAGVSIKY LEDVPKHFKW QSLSIIRCQL KQFPTLDLPF
350 351
LKSLTLTMNK GSISFKKVAL PSLSYLDLSR NALSFSGCCS YSDLGTNSLR
400 401
HLDLSFNGAI IMSANFMGLE ELQHLDFQHS TLKRVTEFSA FLSLEKLLYL
450 451
DISYTNTKID FDGIFLGLTS LNTLKMAGNS FKDNTLSNVF ANTTNLTFLD
500 501
LSKCQLEQIS WGVFDTLHRL QLLNMSHNNL LFLDSSHYNQ LYSLSTLDCS
550 551
FNRIETSKGI LQHFPKSLAF FNLTNNSVAC ICEHQKFLQW VKEQKQFLVN
600 601
VEQMTCATPV EMNTSLVLDF NNSTCYMYKT IISVSVVSVI VVSTVAFLIY
650 651
HFYFHLILIA GCKKYSRGES IYDAFVIYSS QNEDWVRNEL VKNLEEGVPR
700 701
FHLCLHYRDF IPGVAIAANI IQEGFHKSRK VIVVVSRHFI QSRWCIFEYE
750 751
IAQTWQFLSS RSGIIFIVLE KVEKSLLRQQ VELYRLLSRN TYLEWEDNPL
800 801
GRHIFWRRLK NALLDGKASN PEQTAEEEQE TATWT
835
Show the unformatted sequence. |
| Checksums: |
CRC64:9C83B59F9A220C17
MD5:8f646d3e9f5c731a4295f8c710eb7208
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| LRR_6 | 370 - 395 | 2Z64 | A | 370 - 395 | Jmol AstexViewer SPICE |
| 3VQ1 | A | 370 - 395 | Jmol AstexViewer SPICE | ||
| B | 370 - 395 | Jmol AstexViewer SPICE | |||
| 3VQ2 | A | 370 - 395 | Jmol AstexViewer SPICE | ||
| B | 370 - 395 | Jmol AstexViewer SPICE | |||
| LRR_8 | 494 - 554 | 2Z64 | A | 494 - 554 | Jmol AstexViewer SPICE |
| 3VQ1 | A | 494 - 554 | Jmol AstexViewer SPICE | ||
| B | 494 - 554 | Jmol AstexViewer SPICE | |||
| 3VQ2 | A | 494 - 554 | Jmol AstexViewer SPICE | ||
| B | 494 - 554 | Jmol AstexViewer SPICE | |||
| 53 - 113 | 2Z64 | A | 53 - 113 | Jmol AstexViewer SPICE | |
| 3VQ1 | A | 53 - 113 | Jmol AstexViewer SPICE | ||
| B | 53 - 113 | Jmol AstexViewer SPICE | |||
| 3VQ2 | A | 53 - 113 | Jmol AstexViewer SPICE | ||
| B | 53 - 113 | Jmol AstexViewer SPICE | |||
| 89 - 137 | 2Z64 | A | 89 - 137 | Jmol AstexViewer SPICE | |
| 3VQ1 | A | 89 - 137 | Jmol AstexViewer SPICE | ||
| B | 89 - 137 | Jmol AstexViewer SPICE | |||
| 3VQ2 | A | 89 - 137 | Jmol AstexViewer SPICE | ||
| B | 89 - 137 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.