Summary
This is the summary of UniProt entry DPOLL_HUMAN (Q9UGP5).
| Description: | DNA polymerase lambda EC=2.7.7.7 EC=4.2.99.- |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 575 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 27 | 28 |
| low_complexity | n/a | 32 | 39 |
| disorder | n/a | 77 | 79 |
| low_complexity | n/a | 93 | 109 |
| disorder | n/a | 143 | 211 |
| low_complexity | n/a | 168 | 179 |
| disorder | n/a | 220 | 228 |
| disorder | n/a | 238 | 242 |
| disorder | n/a | 250 | 254 |
| Pfam A | HHH_8 | 253 | 318 |
| Pfam A | DNA_pol_lambd_f | 335 | 385 |
| Pfam A | DNA_pol_B_palm | 386 | 496 |
| disorder | n/a | 394 | 398 |
| disorder | n/a | 473 | 475 |
| low_complexity | n/a | 478 | 489 |
| Pfam A | DNA_pol_B_thumb | 502 | 575 |
| disorder | n/a | 546 | 548 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UGP5. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MDPRGILKAF PKRQKIHADA SSKVLAKIPR REEGEEAEEW LSSLRAHVVR
50 51
TGIGRARAEL FEKQIVQHGG QLCPAQGPGV THIVVDEGMD YERALRLLRL
100 101
PQLPPGAQLV KSAWLSLCLQ ERRLVDVAGF SIFIPSRYLD HPQPSKAEQD
150 151
ASIPPGTHEA LLQTALSPPP PPTRPVSPPQ KAKEAPNTQA QPISDDEASD
200 201
GEETQVSAAD LEALISGHYP TSLEGDCEPS PAPAVLDKWV CAQPSSQKAT
250 251
NHNLHITEKL EVLAKAYSVQ GDKWRALGYA KAINALKSFH KPVTSYQEAC
300 301
SIPGIGKRMA EKIIEILESG HLRKLDHISE SVPVLELFSN IWGAGTKTAQ
350 351
MWYQQGFRSL EDIRSQASLT TQQAIGLKHY SDFLERMPRE EATEIEQTVQ
400 401
KAAQAFNSGL LCVACGSYRR GKATCGDVDV LITHPDGRSH RGIFSRLLDS
450 451
LRQEGFLTDD LVSQEENGQQ QKYLGVCRLP GPGRRHRRLD IIVVPYSEFA
500 501
CALLYFTGSA HFNRSMRALA KTKGMSLSEH ALSTAVVRNT HGCKVGPGRV
550 551
LPTPTEKDVF RLLGLPYREP AERDW
575
Show the unformatted sequence. |
| Checksums: |
CRC64:FD9196A1C94923C4
MD5:c120becf7108838ff7988a98dd572fe1
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.