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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ERRFI_HUMAN (Q9UJM3)

Summary

This is the summary of UniProt entry ERRFI_HUMAN (Q9UJM3).

Description: ERBB receptor feedback inhibitor 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 462 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A GTPase_binding 4 68
disorder n/a 31 32
disorder n/a 66 68
Pfam B Pfam-B_81 71 189
disorder n/a 76 84
low_complexity n/a 86 103
disorder n/a 91 101
disorder n/a 156 159
disorder n/a 222 256
low_complexity n/a 227 241
disorder n/a 268 371
low_complexity n/a 280 296
Pfam A Inhibitor_Mig-6 315 372
disorder n/a 374 377
disorder n/a 394 395
disorder n/a 407 411
disorder n/a 414 448

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UJM3. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSIAGVAAQE IRVPLKTGFL HNGRAMGNMR KTYWSSRSEF KNNFLNIDPI
50
51
TMAYSLNSSA QERLIPLGHA SKSAPMNGHC FAENGPSQKS SLPPLLIPPS
100
101
ENLGPHEEDQ VVCGFKKLTV NGVCASTPPL TPIKNSPSLF PCAPLCERGS
150
151
RPLPPLPISE ALSLDDTDCE VEFLTSSDTD FLLEDSTLSD FKYDVPGRRS
200
201
FRGCGQINYA YFDTPAVSAA DLSYVSDQNG GVPDPNPPPP QTHRRLRRSH
250
251
SGPAGSFNKP AIRISNCCIH RASPNSDEDK PEVPPRVPIP PRPVKPDYRR
300
301
WSAEVTSSTY SDEDRPPKVP PREPLSPSNS RTPSPKSLPS YLNGVMPPTQ
350
351
SFAPDPKYVS SKALQRQNSE GSASKVPCIL PIIENGKKVS STHYYLLPER
400
401
PPYLDKYEKF FREAEETNGG AQIQPLPADC GISSATEKPD SKTKMDLGGH
450
451
VKRKHLSYVV SP                                         
462
 

Show the unformatted sequence.

Checksums:
CRC64:7AFA9F6CEB602912
MD5:b7ad501efee26b3f1dee1f11a84fcab2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Inhibitor_Mig-6 336 - 362 2RF9 C 336 - 362 Jmol AstexViewer SPICE
337 - 360 2RFE F 337 - 360 Jmol AstexViewer SPICE
337 - 362 2RF9 D 337 - 362 Jmol AstexViewer SPICE
2RFE E 337 - 362 Jmol AstexViewer SPICE
346 - 360 2RFD D 346 - 360 Jmol AstexViewer SPICE
346 - 361 2RFD C 346 - 361 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.