Summary
This is the summary of UniProt entry HCN2_HUMAN (Q9UL51).
| Description: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 889 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 159 |
| low_complexity | n/a | 4 | 68 |
| low_complexity | n/a | 129 | 155 |
| disorder | n/a | 161 | 163 |
| Pfam A | Ion_trans_N | 166 | 242 |
| transmembrane | n/a | 212 | 236 |
| transmembrane | n/a | 242 | 261 |
| Pfam A | Ion_trans | 246 | 462 |
| transmembrane | n/a | 290 | 308 |
| transmembrane | n/a | 320 | 338 |
| low_complexity | n/a | 331 | 345 |
| transmembrane | n/a | 358 | 377 |
| transmembrane | n/a | 413 | 431 |
| transmembrane | n/a | 443 | 466 |
| low_complexity | n/a | 475 | 486 |
| Pfam A | cNMP_binding | 562 | 647 |
| Pfam B | Pfam-B_4899 | 665 | 699 |
| disorder | n/a | 706 | 729 |
| low_complexity | n/a | 715 | 721 |
| disorder | n/a | 750 | 889 |
| low_complexity | n/a | 759 | 790 |
| low_complexity | n/a | 793 | 828 |
| low_complexity | n/a | 830 | 847 |
| low_complexity | n/a | 852 | 869 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UL51. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MDARGGGGRP GESPGATPAP GPPPPPPPAP PQQQPPPPPP PAPPPGPGPA
50 51
PPQHPPRAEA LPPEAADEGG PRGRLRSRDS SCGRPGTPGA ASTAKGSPNG
100 101
ECGRGEPQCS PAGPEGPARG PKVSFSCRGA ASGPAPGPGP AEEAGSEEAG
150 151
PAGEPRGSQA SFMQRQFGAL LQPGVNKFSL RMFGSQKAVE REQERVKSAG
200 201
AWIIHPYSDF RFYWDFTMLL FMVGNLIIIP VGITFFKDET TAPWIVFNVV
250 251
SDTFFLMDLV LNFRTGIVIE DNTEIILDPE KIKKKYLRTW FVVDFVSSIP
300 301
VDYIFLIVEK GIDSEVYKTA RALRIVRFTK ILSLLRLLRL SRLIRYIHQW
350 351
EEIFHMTYDL ASAVMRICNL ISMMLLLCHW DGCLQFLVPM LQDFPRNCWV
400 401
SINGMVNHSW SELYSFALFK AMSHMLCIGY GRQAPESMTD IWLTMLSMIV
450 451
GATCYAMFIG HATALIQSLD SSRRQYQEKY KQVEQYMSFH KLPADFRQKI
500 501
HDYYEHRYQG KMFDEDSILG ELNGPLREEI VNFNCRKLVA SMPLFANADP
550 551
NFVTAMLTKL KFEVFQPGDY IIREGTIGKK MYFIQHGVVS VLTKGNKEMK
600 601
LSDGSYFGEI CLLTRGRRTA SVRADTYCRL YSLSVDNFNE VLEEYPMMRR
650 651
AFETVAIDRL DRIGKKNSIL LHKVQHDLNS GVFNNQENAI IQEIVKYDRE
700 701
MVQQAELGQR VGLFPPPPPP PQVTSAIATL QQAAAMSFCP QVARPLVGPL
750 751
ALGSPRLVRR PPPGPAPAAA SPGPPPPASP PGAPASPRAP RTSPYGGLPA
800 801
APLAGPALPA RRLSRASRPL SASQPSLPHG APGPAASTRP ASSSTPRLGP
850 851
TPAARAAAPS PDRRDSASPG AAGGLDPQDS ARSRLSSNL
889
Show the unformatted sequence. |
| Checksums: |
CRC64:4B263E0C06C2A47D
MD5:19163822d53ef06530f0730234fde9a6
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| cNMP_binding | 562 - 647 | 3U10 | A | 562 - 647 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.