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8  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PPIE_HUMAN (Q9UNP9)

Summary

This is the summary of UniProt entry PPIE_HUMAN (Q9UNP9).

Description: Peptidyl-prolyl cis-trans isomerase E EC=5.2.1.8
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 301 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A RRM_1 8 78
disorder n/a 107 136
low_complexity n/a 111 120
Pfam A Pro_isomerase 143 299
disorder n/a 143 144
disorder n/a 159 160
disorder n/a 236 237
disorder n/a 279 280

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UNP9. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MATTKRVLYV GGLAEEVDDK VLHAAFIPFG DITDIQIPLD YETEKHRGFA
50
51
FVEFELAEDA AAAIDNMNES ELFGRTIRVN LAKPMRIKEG SSRPVWSDDD
100
101
WLKKFSGKTL EENKEEEGSE PPKAETQEGE PIAKKARSNP QVYMDIKIGN
150
151
KPAGRIQMLL RSDVVPMTAE NFRCLCTHEK GFGFKGSSFH RIIPQFMCQG
200
201
GDFTNHNGTG GKSIYGKKFD DENFILKHTG PGLLSMANSG PNTNGSQFFL
250
251
TCDKTDWLDG KHVVFGEVTE GLDVLRQIEA QGSKDGKPKQ KVIIADCGEY
300
301
V                                                     
301
 

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Checksums:
CRC64:F3226149A790BA42
MD5:bf7aca086ab6540999ea039157672914

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pro_isomerase 143 - 299 1ZMF A 143 - 299 Jmol AstexViewer SPICE
2R99 A 143 - 299 Jmol AstexViewer SPICE
3UCH A 143 - 299 Jmol AstexViewer SPICE
RRM_1 8 - 78 2CQB A 8 - 78 Jmol AstexViewer SPICE
2KU7 A 66 - 136 Jmol AstexViewer SPICE
2KYX A 8 - 78 Jmol AstexViewer SPICE
3LPY A 8 - 78 Jmol AstexViewer SPICE
B 8 - 78 Jmol AstexViewer SPICE
3MDF A 8 - 78 Jmol AstexViewer SPICE
B 8 - 78 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.