Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PIN4_HUMAN (Q9Y237)

Summary

This is the summary of UniProt entry PIN4_HUMAN (Q9Y237).

Description: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 EC=5.2.1.8
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 131 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 1 40
low_complexity n/a 4 28
Pfam A Rotamase_3 21 131
disorder n/a 66 72
disorder n/a 75 87

Show or hide domain scores.

Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

Note: it can take a few seconds for this image to be generated and loaded.

Loading feature alignment...

Show sources update panel.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Y237. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPPKGKSGSG KAGKGGAASG SDSADKKAQG PKGGGNAVKV RHILCEKHGK
50
51
IMEAMEKLKS GMRFNEVAAQ YSEDKARQGG DLGWMTRGSM VGPFQEAAFA
100
101
LPVSGMDKPV FTDPPVKTKF GYHIIMVEGR K                    
131
 

Show the unformatted sequence.

Checksums:
CRC64:787C15BDB0701258
MD5:25a4569cab9b98b32ba4e0877e0fddaa

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Rotamase_3 30 - 131 1FJD A 30 - 131 Jmol AstexViewer SPICE
36 - 131 1EQ3 A 36 - 131 Jmol AstexViewer SPICE
3UI4 A 36 - 131 Jmol AstexViewer SPICE
3UI5 A 36 - 131 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.