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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: MAN1_HUMAN (Q9Y2U8)

Summary

This is the summary of UniProt entry MAN1_HUMAN (Q9Y2U8).

Description: Inner nuclear membrane protein Man1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 911 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 1 14
low_complexity n/a 2 8
Pfam A LEM 7 49
disorder n/a 16 79
low_complexity n/a 40 53
Pfam B Pfam-B_80410 50 119
low_complexity n/a 57 90
disorder n/a 84 88
disorder n/a 94 96
disorder n/a 105 106
disorder n/a 111 246
low_complexity n/a 111 133
low_complexity n/a 214 236
disorder n/a 249 386
low_complexity n/a 259 268
low_complexity n/a 335 341
low_complexity n/a 364 389
low_complexity n/a 407 422
disorder n/a 421 422
disorder n/a 433 445
low_complexity n/a 443 454
disorder n/a 447 460
transmembrane n/a 472 493
Pfam A MSC 503 751
low_complexity n/a 629 650
transmembrane n/a 635 652
Pfam B Pfam-B_19423 851 889
disorder n/a 879 880
disorder n/a 882 888
disorder n/a 890 892
disorder n/a 896 901
disorder n/a 909 911

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Y2U8. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAAAASAPQ QLSDEELFSQ LRRYGLSPGP VTESTRPVYL KKLKKLREEE
50
51
QQQHRSGGRG NKTRNSNNNN TAAATVAAAG PAAAAAAGMG VRPVSGDLSY
100
101
LRTPGGLCRI SASGPESLLG GPGGASAAPA AGSKVLLGFS SDESDVEASP
150
151
RDQAGGGGRK DRASLQYRGL KAPPAPLAAS EVTNSNSAER RKPHSWWGAR
200
201
RPAGPELQTP PGKDGAVEDE EGEGEDGEER DPETEEPLWA SRTVNGSRLV
250
251
PYSCRENYSD SEEEDDDDVA SSRQVLKDDS LSRHRPRRTH SKPLPPLTAK
300
301
SAGGRLETSV QGGGGLAMND RAAAAGSLDR SRNLEEAAAA EQGGGCDQVD
350
351
SSPVPRYRVN AKKLTPLLPP PLTDMDSTLD SSTGSLLKTN NHIGGGAFSV
400
401
DSPRIYSNSL PPSAAVAASS SLRINHANHT GSNHTYLKNT YNKPKLSEPE
450
451
EELLQQFKRE EVSPTGSFSA HYLSMFLLTA ACLFFLILGL TYLGMRGTGV
500
501
SEDGELSIEN PFGETFGKIQ ESEKTLMMNT LYKLHDRLAQ LAGDHECGSS
550
551
SQRTLSVQEA AAYLKDLGPE YEGIFNTSLQ WILENGKDVG IRCVGFGPEE
600
601
ELTNITDVQF LQSTRPLMSF WCRFRRAFVT VTHRLLLLCL GVVMVCVVLR
650
651
YMKYRWTKEE EETRQMYDMV VKIIDVLRSH NEACQENKDL QPYMPIPHVR
700
701
DSLIQPHDRK KMKKVWDRAV DFLAANESRV RTETRRIGGA DFLVWRWIQP
750
751
SASCDKILVI PSKVWQGQAF HLDRRNSPPN SLTPCLKIRN MFDPVMEIGD
800
801
QWHLAIQEAI LEKCSDNDGI VHIAVDKNSR EGCVYVKCLS PEYAGKAFKA
850
851
LHGSWFDGKL VTVKYLRLDR YHHRFPQALT SNTPLKPSNK HMNSMSHLRL
900
901
RTGLTNSQGS S                                          
911
 

Show the unformatted sequence.

Checksums:
CRC64:21D1E6BB0D499131
MD5:8f8cf2f9d7681d985178f887ffcf9241

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
MSC 655 - 751 2CH0 A 6 - 102 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.