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14  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NEUR2_HUMAN (Q9Y3R4)

Summary

This is the summary of UniProt entry NEUR2_HUMAN (Q9Y3R4).

Description: Sialidase-2 EC=3.2.1.18
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 380 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam B Pfam-B_25392 1 31
Pfam A BNR_2 32 345
low_complexity n/a 65 77
disorder n/a 136 139
disorder n/a 245 248
disorder n/a 257 260
disorder n/a 275 280
low_complexity n/a 278 289
disorder n/a 306 309
disorder n/a 313 314

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Y3R4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASLPVLQKE SVFQSGAHAY RIPALLYLPG QQSLLAFAEQ RASKKDEHAE
50
51
LIVLRRGDYD APTHQVQWQA QEVVAQARLD GHRSMNPCPL YDAQTGTLFL
100
101
FFIAIPGQVT EQQQLQTRAN VTRLCQVTST DHGRTWSSPR DLTDAAIGPA
150
151
YREWSTFAVG PGHCLQLHDR ARSLVVPAYA YRKLHPIQRP IPSAFCFLSH
200
201
DHGRTWARGH FVAQDTLECQ VAEVETGEQR VVTLNARSHL RARVQAQSTN
250
251
DGLDFQESQL VKKLVEPPPQ GCQGSVISFP SPRSGPGSPA QWLLYTHPTH
300
301
SWQRADLGAY LNPRPPAPEA WSEPVLLAKG SCAYSDLQSM GTGPDGSPLF
350
351
GCLYEANDYE EIVFLMFTLK QAFPAEYLPQ                      
380
 

Show the unformatted sequence.

Checksums:
CRC64:AD7B08C478F4D0D9
MD5:e6ac63ed07ac9b23060e34ebe556fb49

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
BNR_2 32 - 345 1SNT A 32 - 345 Jmol AstexViewer SPICE
1SO7 A 32 - 345 Jmol AstexViewer SPICE
1VCU A 32 - 345 Jmol AstexViewer SPICE
B 32 - 345 Jmol AstexViewer SPICE
2F0Z A 32 - 345 Jmol AstexViewer SPICE
2F10 A 32 - 345 Jmol AstexViewer SPICE
2F11 A 32 - 345 Jmol AstexViewer SPICE
2F12 A 32 - 345 Jmol AstexViewer SPICE
2F13 A 32 - 345 Jmol AstexViewer SPICE
2F24 A 32 - 345 Jmol AstexViewer SPICE
2F25 A 32 - 345 Jmol AstexViewer SPICE
B 32 - 345 Jmol AstexViewer SPICE
2F26 A 32 - 345 Jmol AstexViewer SPICE
2F27 A 32 - 345 Jmol AstexViewer SPICE
B 32 - 345 Jmol AstexViewer SPICE
2F28 A 32 - 345 Jmol AstexViewer SPICE
2F29 A 32 - 345 Jmol AstexViewer SPICE
B 32 - 345 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.