Summary
This is the summary of UniProt entry RPGF2_HUMAN (Q9Y4G8).
| Description: | Rap guanine nucleotide exchange factor 2 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 1499 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 29 |
| disorder | n/a | 32 | 53 |
| low_complexity | n/a | 38 | 62 |
| disorder | n/a | 56 | 66 |
| disorder | n/a | 68 | 99 |
| low_complexity | n/a | 84 | 95 |
| disorder | n/a | 113 | 114 |
| Pfam A | cNMP_binding | 155 | 240 |
| coiled_coil | n/a | 228 | 248 |
| disorder | n/a | 256 | 257 |
| Pfam A | RasGEF_N | 270 | 357 |
| low_complexity | n/a | 352 | 364 |
| Pfam A | PDZ | 387 | 465 |
| disorder | n/a | 481 | 482 |
| disorder | n/a | 485 | 490 |
| disorder | n/a | 529 | 530 |
| disorder | n/a | 575 | 578 |
| disorder | n/a | 583 | 584 |
| Pfam A | RA | 606 | 692 |
| Pfam A | RasGEF | 714 | 899 |
| disorder | n/a | 939 | 950 |
| disorder | n/a | 954 | 956 |
| disorder | n/a | 958 | 959 |
| disorder | n/a | 979 | 981 |
| disorder | n/a | 992 | 1079 |
| low_complexity | n/a | 1031 | 1046 |
| disorder | n/a | 1081 | 1085 |
| disorder | n/a | 1087 | 1155 |
| low_complexity | n/a | 1111 | 1125 |
| low_complexity | n/a | 1141 | 1162 |
| disorder | n/a | 1159 | 1203 |
| disorder | n/a | 1206 | 1207 |
| disorder | n/a | 1213 | 1257 |
| disorder | n/a | 1259 | 1269 |
| disorder | n/a | 1274 | 1276 |
| disorder | n/a | 1285 | 1286 |
| disorder | n/a | 1292 | 1295 |
| disorder | n/a | 1300 | 1499 |
| low_complexity | n/a | 1355 | 1369 |
| low_complexity | n/a | 1393 | 1412 |
| Pfam B | Pfam-B_41394 | 1469 | 1497 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Y4G8. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MKPLAIPANH GVMGQQEKHS LPADFTKLHL TDSLHPQVTH VSSSHSGCSI
50 51
TSDSGSSSLS DIYQATESEA GDMDLSGLPE TAVDSEDDDD EEDIERASDP
100 101
LMSRDIVRDC LEKDPIDRTD DDIEQLLEFM HQLPAFANMT MSVRRELCAV
150 151
MVFAVVERAG TIVLNDGEEL DSWSVILNGS VEVTYPDGKA EILCMGNSFG
200 201
VSPTMDKEYM KGVMRTKVDD CQFVCIAQQD YCRILNQVEK NMQKVEEEGE
250 251
IVMVKEHREL DRTGTRKGHI VIKGTSERLT MHLVEEHSVV DPTFIEDFLL
300 301
TYRTFLSSPM EVGKKLLEWF NDPSLRDKVT RVVLLWVNNH FNDFEGDPAM
350 351
TRFLEEFENN LEREKMGGHL RLLNIACAAK AKRRLMTLTK PSREAPLPFI
400 401
LLGGSEKGFG IFVDSVDSGS KATEAGLKRG DQILEVNGQN FENIQLSKAM
450 451
EILRNNTHLS ITVKTNLFVF KELLTRLSEE KRNGAPHLPK IGDIKKASRY
500 501
SIPDLAVDVE QVIGLEKVNK KSKANTVGGR NKLKKILDKT RISILPQKPY
550 551
NDIGIGQSQD DSIVGLRQTK HIPTALPVSG TLSSSNPDLL QSHHRILDFS
600 601
ATPDLPDQVL RVFKADQQSR YIMISKDTTA KEVVIQAIRE FAVTATPDQY
650 651
SLCEVSVTPE GVIKQRRLPD QLSKLADRIQ LSGRYYLKNN METETLCSDE
700 701
DAQELLRESQ ISLLQLSTVE VATQLSMRNF ELFRNIEPTE YIDDLFKLRS
750 751
KTSCANLKRF EEVINQETFW VASEILRETN QLKRMKIIKH FIKIALHCRE
800 801
CKNFNSMFAI ISGLNLAPVA RLRTTWEKLP NKYEKLFQDL QDLFDPSRNM
850 851
AKYRNVLNSQ NLQPPIIPLF PVIKKDLTFL HEGNDSKVDG LVNFEKLRMI
900 901
AKEIRHVGRM ASVNMDPALM FRTRKKKWRS LGSLSQGSTN ATVLDVAQTG
950 951
GHKKRVRRSS FLNAKKLYED AQMARKVKQY LSNLELEMDE ESLQTLSLQC
1000 1001
EPATNTLPKN PGDKKPVKSE TSPVAPRAGS QQKAQSLPQP QQQPPPAHKI
1050 1051
NQGLQVPAVS LYPSRKKVPV KDLPPFGINS PQALKKILSL SEEGSLERHK
1100 1101
KQAEDTISNA SSQLSSPPTS PQSSPRKGYT LAPSGTVDNF SDSGHSEISS
1150 1151
RSSIVSNSSF DSVPVSLHDE RRQRHSVSIV ETNLGMGRME RRTMIEPDQY
1200 1201
SLGSYAPMSE GRGLYATATV ISSPSTEELS QDQGDRASLD AADSGRGSWT
1250 1251
SCSSGSHDNI QTIQHQRSWE TLPFGHTHFD YSGDPAGLWA SSSHMDQIMF
1300 1301
SDHSTKYNRQ NQSRESLEQA QSRASWASST GYWGEDSEGD TGTIKRRGGK
1350 1351
DVSIEAESSS LTSVTTEETK PVPMPAHIAV ASSTTKGLIA RKEGRYREPP
1400 1401
PTPPGYIGIP ITDFPEGHSH PARKPPDYNV ALQRSRMVAR SSDTAGPSSV
1450 1451
QQPHGHPTSS RPVNKPQWHK PNESDPRLAP YQSQGFSTEE DEDEQVSAV
1499
Show the unformatted sequence. |
| Checksums: |
CRC64:1909E8A12637E001
MD5:a14bbbf1443438bfbf55353848b7148b
|
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.