Summary
This is the summary of UniProt entry BACE2_HUMAN (Q9Y5Z0).
| Description: | Beta-secretase 2 EC=3.4.23.45 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 518 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam B | Pfam-B_60469 | 1 | 69 |
| sig_p | n/a | 1 | 20 |
| low_complexity | n/a | 3 | 28 |
| disorder | n/a | 42 | 57 |
| low_complexity | n/a | 57 | 79 |
| Pfam A | Asp | 91 | 431 |
| transmembrane | n/a | 467 | 492 |
| low_complexity | n/a | 482 | 492 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Y5Z0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MGALARALLL PLLAQWLLRA APELAPAPFT LPLRVAAATN RVVAPTPGPG
50 51
TPAERHADGL ALALEPALAS PAGAANFLAM VDNLQGDSGR GYYLEMLIGT
100 101
PPQKLQILVD TGSSNFAVAG TPHSYIDTYF DTERSSTYRS KGFDVTVKYT
150 151
QGSWTGFVGE DLVTIPKGFN TSFLVNIATI FESENFFLPG IKWNGILGLA
200 201
YATLAKPSSS LETFFDSLVT QANIPNVFSM QMCGAGLPVA GSGTNGGSLV
250 251
LGGIEPSLYK GDIWYTPIKE EWYYQIEILK LEIGGQSLNL DCREYNADKA
300 301
IVDSGTTLLR LPQKVFDAVV EAVARASLIP EFSDGFWTGS QLACWTNSET
350 351
PWSYFPKISI YLRDENSSRS FRITILPQLY IQPMMGAGLN YECYRFGISP
400 401
STNALVIGAT VMEGFYVIFD RAQKRVGFAA SPCAEIAGAA VSEISGPFST
450 451
EDVASNCVPA QSLSEPILWI VSYALMSVCG AILLVLIVLL LLPFRCQRRP
500 501
RDPEVVNDES SLVRHRWK
518
Show the unformatted sequence. |
| Checksums: |
CRC64:2E903150823760D3
MD5:b4a3175b423b5e0d291d58e471028336
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Asp | 91 - 431 | 2EWY | A | 29 - 369 | Jmol AstexViewer SPICE |
| B | 29 - 369 | Jmol AstexViewer SPICE | |||
| C | 29 - 369 | Jmol AstexViewer SPICE | |||
| D | 29 - 369 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.