Summary
This is the summary of UniProt entry ZO2_MOUSE (Q9Z0U1).
| Description: | Tight junction protein ZO-2 |
| Source organism: |
Mus musculus (Mouse)
(NCBI taxonomy ID
10090)
View Pfam proteome data. |
| Length: | 1167 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam A | PDZ | 10 | 94 |
| disorder | n/a | 24 | 29 |
| disorder | n/a | 34 | 43 |
| disorder | n/a | 57 | 62 |
| disorder | n/a | 75 | 76 |
| disorder | n/a | 97 | 118 |
| disorder | n/a | 128 | 291 |
| low_complexity | n/a | 163 | 178 |
| low_complexity | n/a | 181 | 202 |
| low_complexity | n/a | 209 | 226 |
| low_complexity | n/a | 253 | 276 |
| Pfam A | PDZ | 280 | 362 |
| disorder | n/a | 314 | 325 |
| disorder | n/a | 328 | 337 |
| disorder | n/a | 341 | 349 |
| disorder | n/a | 370 | 483 |
| low_complexity | n/a | 377 | 390 |
| disorder | n/a | 485 | 491 |
| Pfam A | PDZ | 490 | 569 |
| disorder | n/a | 522 | 532 |
| Pfam A | SH3_2 | 588 | 647 |
| disorder | n/a | 645 | 654 |
| disorder | n/a | 662 | 665 |
| disorder | n/a | 676 | 680 |
| disorder | n/a | 737 | 752 |
| Pfam A | Guanylate_kin | 751 | 860 |
| disorder | n/a | 805 | 810 |
| disorder | n/a | 851 | 853 |
| disorder | n/a | 861 | 874 |
| disorder | n/a | 876 | 884 |
| Pfam B | Pfam-B_9253 | 881 | 936 |
| disorder | n/a | 899 | 902 |
| disorder | n/a | 904 | 1167 |
| low_complexity | n/a | 969 | 980 |
| low_complexity | n/a | 1037 | 1049 |
| Pfam B | Pfam-B_15390 | 1060 | 1102 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Z0U1. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MEEVIWEQYT VTLQKDSKRG FGIAVSGGRD NPHFENGETS IVISDVLPGG
50 51
PADGLLQEND RVVMVNGTPM EDVLHSFAVQ QLRKSGKIAA IVVKRPRKVQ
100 101
VAPLQGSPPL SHDDRGFEVI EEFDGRSFRS GYSERSRHSS HDMLSHSWEG
150 151
NRERGRPHQR TQSRERERSR GRSLERGLDQ EDYGRSRERS RGRSLERGLD
200 201
RDFVSRDHSR GRSIDRDYDR DYERSYHEAY EPDYGGGYSP SYDRRAHPET
250 251
RYERSRSREH LRSRSPSPES RSRHEHKGQH DPDRPIGVLL TKSKANEEYG
300 301
LRLGSQIFIK EMTRTGLATK DGNLHEGDII LKINGTVTEN MSLTDARKLI
350 351
EKSRGKLQLV VLRDSKQTLI NIPALNDSDS EVEDISEIES NRSFSPEERR
400 401
QQYSDQDYHS STEKLKERPS SREETSGRLS RMGATPTPFK STGDITAAGV
450 451
TEASREPRYQ EEGPVPQPRT APRVFLRPSP EDEAIYGPNT KMVRFKKGDS
500 501
VGLRLAGGND VGIFVAGIQE GTSAEQEGLQ EGDQILKVNT QDFRGLVRED
550 551
AVLYLLEIPK GETVTILAQS RADVYRDILA CGRGDSFFIR SHFECEKETP
600 601
QSLAFTRGEV FRVVDTLYDG KLGHWLAVRI GNELEKGLIP NKSRAEQMAS
650 651
VQNAQRENAG DRADFWRMRG QRSSGGVKKN LRKSREDLAA AVSVSTKFPA
700 701
YEKVLLREAG FKRPVVLFGP IADIAMERLA TELPDLFQTA KTEPKDAGSE
750 751
KSSGVVRLNT VRQIIEQDKH ALLDVTPKAV DLLNYTQWFP IVIFFNPDSR
800 801
QGVKTIRQRL SPTSNKSSRK LFDQANKLKK TCSHLFTATI NVNSANDGWF
850 851
GSLKDSIQQQ QNEAVWVSEG KMEGMDDDAE DRMSYLTAMG ADYLSCDSRL
900 901
ISDFEDTDGE GGAYTDNELE EPAEEPLVSS ITRSSEPVQH EENIRKSSPE
950 951
PRAQMRRAAS RDQLRDASPP PAFKPEPPKA RSQNREDSFD YSKSNLPATA
1000 1001
GSEIPGGSTK GYPPPIAAKP AFGRPILKPS TPVPMPESEE VGESTEEQED
1050 1051
APRSVLGRVK IFEKMDHKAK LQRMQELQEA QNARIEIAQK HPDIYAVPIK
1100 1101
APKPDAGLPP HMSSRPPEPQ KAPSRLYQDT RGSYGSDPEE EEYRQQLAAH
1150 1151
SKRGYYSQPS RYRDTEL
1167
Show the unformatted sequence. |
| Checksums: |
CRC64:C29AF94F423A3A70
MD5:87a7f5b9a61d42632c4d655d10dfeac6
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| PDZ | 10 - 94 | 2CSJ | A | 17 - 101 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.