Summary
This is the summary of UniProt entry VAV_HUMAN (P15498).
| Description: | Proto-oncogene vav |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 845 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam A | CH | 4 | 119 |
| low_complexity | n/a | 42 | 51 |
| disorder | n/a | 128 | 129 |
| disorder | n/a | 140 | 141 |
| disorder | n/a | 160 | 161 |
| disorder | n/a | 173 | 177 |
| disorder | n/a | 179 | 180 |
| Pfam A | RhoGEF | 198 | 372 |
| low_complexity | n/a | 356 | 367 |
| Pfam A | PH | 403 | 504 |
| Pfam A | C1_1 | 516 | 568 |
| disorder | n/a | 568 | 588 |
| Pfam A | SH3_1 | 615 | 652 |
| disorder | n/a | 635 | 636 |
| Pfam A | SH2 | 671 | 745 |
| Pfam A | SH3_1 | 788 | 834 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P15498. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MELWRQCTHW LIQCRVLPPS HRVTWDGAQV CELAQALRDG VLLCQLLNNL
50 51
LPHAINLREV NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF
100 101
DVQDFGKVIY TLSALSWTPI AQNRGIMPFP TEEESVGDED IYSGLSDQID
150 151
DTVEEDEDLY DCVENEEAEG DEIYEDLMRS EPVSMPPKMT EYDKRCCCLR
200 201
EIQQTEEKYT DTLGSIQQHF LKPLQRFLKP QDIEIIFINI EDLLRVHTHF
250 251
LKEMKEALGT PGAANLYQVF IKYKERFLVY GRYCSQVESA SKHLDRVAAA
300 301
REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQEA
350 351
MEKENLRLAL DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLAHY
400 401
GRPKIDGELK ITSVERRSKM DRYAFLLDKA LLICKRRGDS YDLKDFVNLH
450 451
SFQVRDDSSG DRDNKKWSHM FLLIEDQGAQ GYELFFKTRE LKKKWMEQFE
500 501
MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF YQGYRCHRCR
550 551
ASAHKECLGR VPPCGRHGQD FPGTMKKDKL HRRAQDKKRN ELGLPKMEVF
600 601
QEYYGLPPPP GAIGPFLRLN PGDIVELTKA EAEQNWWEGR NTSTNEIGWF
650 651
PCNRVKPYVH GPPQDLSVHL WYAGPMERAG AESILANRSD GTFLVRQRVK
700 701
DAAEFAISIK YNVEVKHIKI MTAEGLYRIT EKKAFRGLTE LVEFYQQNSL
750 751
KDCFKSLDTT LQFPFKEPEK RTISRPAVGS TKYFGTAKAR YDFCARDRSE
800 801
LSLKEGDIIK ILNKKGQQGW WRGEIYGRVG WFPANYVEED YSEYC
845
Show the unformatted sequence. |
| Checksums: |
CRC64:AC3BC9736FD2F138
MD5:3b6f9f9024015da2af565d5489f71d1a
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| C1_1 | 516 - 564 | 3KY9 | A | 516 - 564 | Jmol AstexViewer SPICE |
| 516 - 565 | 3BJI | A | 516 - 565 | Jmol AstexViewer SPICE | |
| B | 516 - 565 | Jmol AstexViewer SPICE | |||
| 3KY9 | B | 516 - 565 | Jmol AstexViewer SPICE | ||
| CH | 4 - 119 | 3KY9 | A | 4 - 119 | Jmol AstexViewer SPICE |
| B | 4 - 119 | Jmol AstexViewer SPICE | |||
| PH | 403 - 504 | 3BJI | A | 403 - 504 | Jmol AstexViewer SPICE |
| B | 403 - 504 | Jmol AstexViewer SPICE | |||
| 3KY9 | A | 403 - 504 | Jmol AstexViewer SPICE | ||
| B | 403 - 504 | Jmol AstexViewer SPICE | |||
| RhoGEF | 198 - 372 | 3BJI | A | 198 - 372 | Jmol AstexViewer SPICE |
| B | 198 - 372 | Jmol AstexViewer SPICE | |||
| 3KY9 | A | 198 - 372 | Jmol AstexViewer SPICE | ||
| B | 198 - 372 | Jmol AstexViewer SPICE | |||
| SH2 | 671 - 745 | 2CRH | A | 28 - 102 | Jmol AstexViewer SPICE |
| 2LCT | A | 671 - 745 | Jmol AstexViewer SPICE | ||
| 2ROR | A | 28 - 102 | Jmol AstexViewer SPICE | ||
| SH3_1 | 629 - 638 | 2CRH | A | 8 - 17 | Jmol AstexViewer SPICE |
| 2ROR | A | 8 - 17 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.