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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: VAV_HUMAN (P15498)

Summary

This is the summary of UniProt entry VAV_HUMAN (P15498).

Description: Proto-oncogene vav
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 845 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A CH 4 119
low_complexity n/a 42 51
disorder n/a 128 129
disorder n/a 140 141
disorder n/a 160 161
disorder n/a 173 177
disorder n/a 179 180
Pfam A RhoGEF 198 372
low_complexity n/a 356 367
Pfam A PH 403 504
Pfam A C1_1 516 568
disorder n/a 568 588
Pfam A SH3_1 615 652
disorder n/a 635 636
Pfam A SH2 671 745
Pfam A SH3_1 788 834

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P15498. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MELWRQCTHW LIQCRVLPPS HRVTWDGAQV CELAQALRDG VLLCQLLNNL
50
51
LPHAINLREV NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF
100
101
DVQDFGKVIY TLSALSWTPI AQNRGIMPFP TEEESVGDED IYSGLSDQID
150
151
DTVEEDEDLY DCVENEEAEG DEIYEDLMRS EPVSMPPKMT EYDKRCCCLR
200
201
EIQQTEEKYT DTLGSIQQHF LKPLQRFLKP QDIEIIFINI EDLLRVHTHF
250
251
LKEMKEALGT PGAANLYQVF IKYKERFLVY GRYCSQVESA SKHLDRVAAA
300
301
REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQEA
350
351
MEKENLRLAL DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLAHY
400
401
GRPKIDGELK ITSVERRSKM DRYAFLLDKA LLICKRRGDS YDLKDFVNLH
450
451
SFQVRDDSSG DRDNKKWSHM FLLIEDQGAQ GYELFFKTRE LKKKWMEQFE
500
501
MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF YQGYRCHRCR
550
551
ASAHKECLGR VPPCGRHGQD FPGTMKKDKL HRRAQDKKRN ELGLPKMEVF
600
601
QEYYGLPPPP GAIGPFLRLN PGDIVELTKA EAEQNWWEGR NTSTNEIGWF
650
651
PCNRVKPYVH GPPQDLSVHL WYAGPMERAG AESILANRSD GTFLVRQRVK
700
701
DAAEFAISIK YNVEVKHIKI MTAEGLYRIT EKKAFRGLTE LVEFYQQNSL
750
751
KDCFKSLDTT LQFPFKEPEK RTISRPAVGS TKYFGTAKAR YDFCARDRSE
800
801
LSLKEGDIIK ILNKKGQQGW WRGEIYGRVG WFPANYVEED YSEYC     
845
 

Show the unformatted sequence.

Checksums:
CRC64:AC3BC9736FD2F138
MD5:3b6f9f9024015da2af565d5489f71d1a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
C1_1 516 - 564 3KY9 A 516 - 564 Jmol AstexViewer SPICE
516 - 565 3BJI A 516 - 565 Jmol AstexViewer SPICE
B 516 - 565 Jmol AstexViewer SPICE
3KY9 B 516 - 565 Jmol AstexViewer SPICE
CH 4 - 119 3KY9 A 4 - 119 Jmol AstexViewer SPICE
B 4 - 119 Jmol AstexViewer SPICE
PH 403 - 504 3BJI A 403 - 504 Jmol AstexViewer SPICE
B 403 - 504 Jmol AstexViewer SPICE
3KY9 A 403 - 504 Jmol AstexViewer SPICE
B 403 - 504 Jmol AstexViewer SPICE
RhoGEF 198 - 372 3BJI A 198 - 372 Jmol AstexViewer SPICE
B 198 - 372 Jmol AstexViewer SPICE
3KY9 A 198 - 372 Jmol AstexViewer SPICE
B 198 - 372 Jmol AstexViewer SPICE
SH2 671 - 745 2CRH A 28 - 102 Jmol AstexViewer SPICE
2LCT A 671 - 745 Jmol AstexViewer SPICE
2ROR A 28 - 102 Jmol AstexViewer SPICE
SH3_1 629 - 638 2CRH A 8 - 17 Jmol AstexViewer SPICE
2ROR A 8 - 17 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.